Data extracted from this reference:
Activating Compound
2.2.1.9
thiamine diphosphate
required, Km: 0.0024 mM
Escherichia coli
Cloned(Commentary)
KM Value [mM]
2.2.1.9
0.053
isochorismate
pH 7.8, 22°C
Escherichia coli
2.2.1.9
1.5
2-oxoglutarate
pH 7.8, 22°C
Escherichia coli
Metals/Ions
2.2.1.9
Mg2+
required, Km: 0.08 mM
Escherichia coli
Natural Substrates/ Products (Substrates)
2.2.1.9
isochorismate + 2-oxoglutarate
Escherichia coli
the enzyme is involved in biosynthesis of vitamin K2 (menoquinone). Under basic conditions, the product can spontaneously lose pyruvate to form (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate
5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2
?
4.2.99.20
5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate
Escherichia coli K-12
the enzyme is involved in biosynthesis of vitamin K2 (manoquinone). Under basic conditions, the product can spontaneously lose pyruvate to form (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate
?
Organism
4.2.99.20
Escherichia coli K-12
Purification (Commentary)
Substrates and Products (Substrate)
2.2.1.9
isochorismate + 2-oxoglutarate
the enzyme is involved in biosynthesis of vitamin K2 (menoquinone). Under basic conditions, the product can spontaneously lose pyruvate to form (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate
685086
Escherichia coli
5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2
?
2.2.1.9
isochorismate + 2-oxoglutarate
under basic conditions, the product can spontaneously lose pyruvate to form (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate
685086
Escherichia coli
5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2
?
4.2.99.20
5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate
685086
Escherichia coli K-12
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate
?
4.2.99.20
5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate
the enzyme is involved in biosynthesis of vitamin K2 (manoquinone). Under basic conditions, the product can spontaneously lose pyruvate to form (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate
685086
Escherichia coli K-12
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate
?
Synonyms
2.2.1.9
MenD
Escherichia coli
2.2.1.9
SEPHCHC synthase
Escherichia coli
4.2.99.20
SHCHC synthase
Escherichia coli K-12
Turnover Number [1/s]
2.2.1.9
0.05
isochorismate
pH 7.8, 22°C
Escherichia coli
2.2.1.9
0.075
2-oxoglutarate
pH 7.8, 22°C
Escherichia coli
pH Optimum
2.2.1.9
7
8
phosphate buffer
Escherichia coli
Activating Compound (protein specific)
2.2.1.9
thiamine diphosphate
required, Km: 0.0024 mM
Escherichia coli
Cloned(Commentary) (protein specific)
KM Value [mM] (protein specific)
2.2.1.9
0.053
isochorismate
pH 7.8, 22°C
Escherichia coli
2.2.1.9
1.5
2-oxoglutarate
pH 7.8, 22°C
Escherichia coli
Metals/Ions (protein specific)
2.2.1.9
Mg2+
required, Km: 0.08 mM
Escherichia coli
Natural Substrates/ Products (Substrates) (protein specific)
2.2.1.9
isochorismate + 2-oxoglutarate
Escherichia coli
the enzyme is involved in biosynthesis of vitamin K2 (menoquinone). Under basic conditions, the product can spontaneously lose pyruvate to form (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate
5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2
?
4.2.99.20
5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate
Escherichia coli K-12
the enzyme is involved in biosynthesis of vitamin K2 (manoquinone). Under basic conditions, the product can spontaneously lose pyruvate to form (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate
?
Purification (Commentary) (protein specific)
Substrates and Products (Substrate) (protein specific)
2.2.1.9
isochorismate + 2-oxoglutarate
the enzyme is involved in biosynthesis of vitamin K2 (menoquinone). Under basic conditions, the product can spontaneously lose pyruvate to form (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate
685086
Escherichia coli
5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2
?
2.2.1.9
isochorismate + 2-oxoglutarate
under basic conditions, the product can spontaneously lose pyruvate to form (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate
685086
Escherichia coli
5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2
?
4.2.99.20
5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate
685086
Escherichia coli K-12
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate
?
4.2.99.20
5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate
the enzyme is involved in biosynthesis of vitamin K2 (manoquinone). Under basic conditions, the product can spontaneously lose pyruvate to form (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate
685086
Escherichia coli K-12
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate
?
Turnover Number [1/s] (protein specific)
2.2.1.9
0.05
isochorismate
pH 7.8, 22°C
Escherichia coli
2.2.1.9
0.075
2-oxoglutarate
pH 7.8, 22°C
Escherichia coli
pH Optimum (protein specific)
2.2.1.9
7
8
phosphate buffer
Escherichia coli