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Literature summary extracted from
- Linoleoyl lysophosphatidic acid and linoleoyl lysophosphatidylcholine are efficient substrates for mammalian lipoxygenases (2007), Biochim. Biophys. Acta, 1770, 1062-1070.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.13.11.31 | additional information | - |
additional information | kinetics with lysophospholipid substrates | Sus scrofa | |
| 1.13.11.31 | 0.0151 | - |
1-linoleoyl lysophosphatidylcholine | pH 7.5, 25°C | Sus scrofa |  |
| 1.13.11.31 | 0.0312 | - |
linoleic acid | pH 7.5, 25°C | Sus scrofa | |
| 1.13.11.31 | 0.0355 | - |
1-linoleoyl lysophosphatidic acid | pH 7.5, 25°C | Sus scrofa | |
| 1.13.11.33 | additional information | - |
additional information | kinetics with lysophospholipid substrates | Oryctolagus cuniculus | |
| 1.13.11.33 | 0.0083 | - |
1-linoleoyl lysophosphatidic acid | pH 7.4, 25°C | Oryctolagus cuniculus | |
| 1.13.11.33 | 0.0121 | - |
linoleic acid | pH 7.4, 25°C | Oryctolagus cuniculus | |
| 1.13.11.33 | 0.0175 | - |
1-linoleoyl lysophosphatidylcholine | pH 7.4, 25°C | Oryctolagus cuniculus | |
| 1.13.11.33 | 0.0717 | - |
dilinoleoyl phosphatidylcholine | pH 7.4, 25°C | Oryctolagus cuniculus | |
| 1.13.11.33 | 0.09 | - |
dilinoleoyl phosphatidic acid | pH 7.4, 25°C | Oryctolagus cuniculus | |
| 1.13.11.34 | additional information | - |
additional information | kinetics with lysophospholipid substrates | Solanum tuberosum | |
| 1.13.11.34 | 0.002 | - |
1-linoleoyl lysophosphatidic acid | pH 6.3, 25°C | Solanum tuberosum | |
| 1.13.11.34 | 0.003 | - |
1-linoleoyl lysophosphatidylcholine | pH 6.3, 25°C | Solanum tuberosum | |
| 1.13.11.34 | 0.004 | - |
linoleic acid | pH 6.3, 25°C | Solanum tuberosum | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.11.31 | arachidonate + O2 | Sus scrofa | - |
(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate | - |
? | |
| 1.13.11.33 | arachidonate + O2 | Oryctolagus cuniculus | - |
(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate | - |
? | |
| 1.13.11.34 | (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | Solanum tuberosum | - |
leukotriene A4 + H2O | - |
? | |
| 1.13.11.34 | arachidonic acid + O2 | Solanum tuberosum | - |
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.13.11.31 | Sus scrofa | - |
- |
- |
| 1.13.11.33 | Oryctolagus cuniculus | - |
- |
- |
| 1.13.11.34 | Solanum tuberosum | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.13.11.31 | commercial preparation | - |
Sus scrofa | - |
| 1.13.11.31 | leukocyte | - |
Sus scrofa | - |
| 1.13.11.33 | commercial preparation | - |
Oryctolagus cuniculus | - |
| 1.13.11.33 | reticulocyte | - |
Oryctolagus cuniculus | - |
| 1.13.11.34 | commercial preparation | - |
Solanum tuberosum | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.13.11.31 | 51.8 | - |
commercial preparation | Sus scrofa |
| 1.13.11.33 | 0.668 | - |
commercial preparation | Oryctolagus cuniculus |
| 1.13.11.34 | 21.9 | - |
commercial prearation | Solanum tuberosum |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.11.31 | 1-linoleoyl lysophosphatidic acid + O2 | i.e. linoleoyl-lysoPA | Sus scrofa | (S)-hydroperoxy 1-linoleoyl lysophosphatidic acid | major product | ? | |
| 1.13.11.31 | 1-linoleoyl lysophosphatidylcholine + O2 | i.e. linoleoyl-lysoPC | Sus scrofa | (S)-hydroperoxy 1-linoleoyl lysophosphatidylcholine | major product | ? | |
| 1.13.11.31 | arachidonate + O2 | - |
Sus scrofa | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate | - |
? | |
| 1.13.11.31 | linoleic acid + O2 | - |
Sus scrofa | (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate | - |
? | |
| 1.13.11.31 | additional information | stereo-selectivity in LOX-catalyzed oxygenation of lysophospholipids, overview | Sus scrofa | ? | - |
? | |
| 1.13.11.33 | 1-linoleoyl lysophosphatidic acid + O2 | i.e. linoleoyl-lysoPA | Oryctolagus cuniculus | (S)-hydroperoxy 1-linoleoyl lysophosphatidic acid | major product | ? | |
| 1.13.11.33 | 1-linoleoyl lysophosphatidylcholine + O2 | i.e. linoleoyl-lysoPC | Oryctolagus cuniculus | (S)-hydroperoxy 1-linoleoyl lysophosphatidylcholine | major product | ? | |
| 1.13.11.33 | arachidonate + O2 | - |
Oryctolagus cuniculus | (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate | - |
? | |
| 1.13.11.33 | dilinoleoyl phosphatidic acid + O2 | i.e. dilinoleoylPA | Oryctolagus cuniculus | (S)-hydroperoxy dilinoleoyl phosphatidic acid | - |
? | |
| 1.13.11.33 | dilinoleoyl phosphatidylcholine + O2 | i.e. dilinoleoylPC | Oryctolagus cuniculus | (S)-hydroperoxy dilinoleoyl phosphatidylcholine | - |
? | |
| 1.13.11.33 | linoleic acid + O2 | - |
Oryctolagus cuniculus | (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate | - |
? | |
| 1.13.11.33 | additional information | stereo-selectivity in LOX-catalyzed oxygenation of lysophospholipids, overview | Oryctolagus cuniculus | ? | - |
? | |
| 1.13.11.34 | (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
Solanum tuberosum | leukotriene A4 + H2O | - |
? | |
| 1.13.11.34 | 1-linoleoyl lysophosphatidic acid + O2 | i.e. linoleoyl-lysoPA | Solanum tuberosum | (S)-hydroperoxy 1-linoleoyl lysophosphatidic acid | major product | ? | |
| 1.13.11.34 | 1-linoleoyl lysophosphatidylcholine + O2 | i.e. linoleoyl-lysoPC | Solanum tuberosum | (S)-hydroperoxy 1-linoleoyl lysophosphatidylcholine | major product | ? | |
| 1.13.11.34 | arachidonic acid + O2 | - |
Solanum tuberosum | (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
? | |
| 1.13.11.34 | linoleic acid + O2 | - |
Solanum tuberosum | (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate | - |
? | |
| 1.13.11.34 | additional information | stereo-selectivity in LOX-catalyzed oxygenation of lysophospholipids, overview | Solanum tuberosum | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.13.11.31 | 12-lipoxygenase | - |
Sus scrofa |
| 1.13.11.33 | reticulocyte-type 15-lipoxygenase | - |
Oryctolagus cuniculus |
| 1.13.11.34 | 5-lipoxygenase | - |
Solanum tuberosum |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.13.11.31 | 25 | - |
assay at | Sus scrofa |
| 1.13.11.33 | 25 | - |
assay at | Oryctolagus cuniculus |
| 1.13.11.34 | 25 | - |
assay at | Solanum tuberosum |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.13.11.31 | 7.5 | - |
assay at | Sus scrofa |
| 1.13.11.33 | 7.4 | - |
assay at | Oryctolagus cuniculus |
| 1.13.11.34 | 6.3 | - |
assay at | Solanum tuberosum |
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