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Literature summary extracted from

  • Scheuch, K.; Lautenschlager, M.; Grohmann, M.; Stahlberg, S.; Kirchheiner, J.; Zill, P.; Heinz, A.; Walther, D.J.; Priller, J.
    Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons (2007), Biol. Psychiatry, 62, 1288-1294.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.14.16.4 additional information polymorphism rs11178997 of the TPH2 promoter significantly reduces TPH2 transcriptional activity by 22% in primary serotonergic neurons. In contrast, no significant differences in promoter activity are observed for the G- and T-alleles of rs4570625. Reduced binding of the transcription factor POU3F2, i.e. Brn-2 or N-Oct-3, to the A-allele occur with the polymorphism rs11178997, while overexpression of POU3F2 results in a robust activation of the TPH2 promoter by about 2.7fold. The human TPH2 promoter is active in rat serotonergic raphe neurons Rattus norvegicus
1.14.16.4 additional information polymorphism rs11178997 of the TPH2 promoter significantly reduces TPH2 transcriptional activity by 7% in SHP-77 cells. In contrast, no significant differences in promoter activity are observed for the G- and T-alleles of rs4570625. Reduced binding of the transcription factor POU3F2, i.e. Brn-2 or N-Oct-3, to the A-allele occur with the polymorphism rs11178997, while overexpression of POU3F2 results in a robust activation of the TPH2 promoter by about 2.7fold, functional assays of TPH2 regulatory region variants, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.16.4 L-tryptophan + tetrahydrobiopterin + O2 Homo sapiens TPH2 is the rate-limiting enzyme in brain serotonin/5-hydroxytryptamine biosynthesis 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
1.14.16.4 L-tryptophan + tetrahydrobiopterin + O2 Rattus norvegicus TPH2 is the rate-limiting enzyme in brain serotonin/5-hydroxytryptamine biosynthesis 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.4 Homo sapiens
-
isozymes TPH1 and TPH2
-
1.14.16.4 Rattus norvegicus Q8CGU9
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.16.4 brain
-
Homo sapiens
-
1.14.16.4 brain raphe nuclei Rattus norvegicus
-
1.14.16.4 neuron primary serotonergic, from raphe nuclei Rattus norvegicus
-
1.14.16.4 SHP-77 cell human small cell lung carcinoma cell line, SHP-77 cells preferentially express TPH1 over TPH2 mRNA Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.4 L-tryptophan + tetrahydrobiopterin + O2
-
Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
1.14.16.4 L-tryptophan + tetrahydrobiopterin + O2
-
Rattus norvegicus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
1.14.16.4 L-tryptophan + tetrahydrobiopterin + O2 TPH2 is the rate-limiting enzyme in brain serotonin/5-hydroxytryptamine biosynthesis Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
1.14.16.4 L-tryptophan + tetrahydrobiopterin + O2 TPH2 is the rate-limiting enzyme in brain serotonin/5-hydroxytryptamine biosynthesis Rattus norvegicus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.16.4 TPH1
-
Homo sapiens
1.14.16.4 TPH2
-
Homo sapiens
1.14.16.4 TPH2
-
Rattus norvegicus
1.14.16.4 tryptophan hydroxylase 2
-
Homo sapiens
1.14.16.4 tryptophan hydroxylase 2
-
Rattus norvegicus