EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.14.16.4 | additional information | polymorphism rs11178997 of the TPH2 promoter significantly reduces TPH2 transcriptional activity by 22% in primary serotonergic neurons. In contrast, no significant differences in promoter activity are observed for the G- and T-alleles of rs4570625. Reduced binding of the transcription factor POU3F2, i.e. Brn-2 or N-Oct-3, to the A-allele occur with the polymorphism rs11178997, while overexpression of POU3F2 results in a robust activation of the TPH2 promoter by about 2.7fold. The human TPH2 promoter is active in rat serotonergic raphe neurons | Rattus norvegicus |
1.14.16.4 | additional information | polymorphism rs11178997 of the TPH2 promoter significantly reduces TPH2 transcriptional activity by 7% in SHP-77 cells. In contrast, no significant differences in promoter activity are observed for the G- and T-alleles of rs4570625. Reduced binding of the transcription factor POU3F2, i.e. Brn-2 or N-Oct-3, to the A-allele occur with the polymorphism rs11178997, while overexpression of POU3F2 results in a robust activation of the TPH2 promoter by about 2.7fold, functional assays of TPH2 regulatory region variants, overview | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 | Homo sapiens | TPH2 is the rate-limiting enzyme in brain serotonin/5-hydroxytryptamine biosynthesis | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 | Rattus norvegicus | TPH2 is the rate-limiting enzyme in brain serotonin/5-hydroxytryptamine biosynthesis | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.16.4 | Homo sapiens | - |
isozymes TPH1 and TPH2 | - |
1.14.16.4 | Rattus norvegicus | Q8CGU9 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.16.4 | brain | - |
Homo sapiens | - |
1.14.16.4 | brain | raphe nuclei | Rattus norvegicus | - |
1.14.16.4 | neuron | primary serotonergic, from raphe nuclei | Rattus norvegicus | - |
1.14.16.4 | SHP-77 cell | human small cell lung carcinoma cell line, SHP-77 cells preferentially express TPH1 over TPH2 mRNA | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 | - |
Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 | TPH2 is the rate-limiting enzyme in brain serotonin/5-hydroxytryptamine biosynthesis | Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 | TPH2 is the rate-limiting enzyme in brain serotonin/5-hydroxytryptamine biosynthesis | Rattus norvegicus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.16.4 | TPH1 | - |
Homo sapiens |
1.14.16.4 | TPH2 | - |
Homo sapiens |
1.14.16.4 | TPH2 | - |
Rattus norvegicus |
1.14.16.4 | tryptophan hydroxylase 2 | - |
Homo sapiens |
1.14.16.4 | tryptophan hydroxylase 2 | - |
Rattus norvegicus |