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Literature summary extracted from

  • Bakavoli, M.; Nikpour, M.; Rahimizadeh, M.; Saberi, M.R.; Sadeghian, H.
    Design and synthesis of pyrimido[4,5-b][1,4]benzothiazine derivatives, as potent 15-lipoxygenase inhibitors (2007), Bioorg. Med. Chem., 15, 2120-2126.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.33 2-(4-ethylpiperazin-1-yl)4-methylpyrimido[4,5-b][1,4]benzothiazine
-
 Glycine max
1.13.11.33 4-methyl-2-(4-hydroxypiperidin-1-yl)pyrimido[4,5-b][1,4]benzothiazine
-
 Glycine max
1.13.11.33 4-methyl-2-(4-methylpiperazin-1-yl)pyrimido[4,5-b][1,4]benzothiazine
-
 Glycine max
1.13.11.33 4-methyl-2-(4-methylpiperidin-1-yl)pyrimido[4,5-b][1,4]benzothiazine
-
 Glycine max
1.13.11.33 4-methyl-2-(4-phenylpiperazin-1-yl)pyrimido[4,5-b][1,4]benzothiazine
-
 Glycine max
1.13.11.33 4-methyl-2-(morpholin-4-yl)pyrimido[4,5-b][1,4]benzothiazine
-
 Glycine max
1.13.11.33 4-methyl-2-(piperidin-1-yl)pyrimido[4,5-b][1,4]benzothiazine
-
 Glycine max
1.13.11.33 4-methyl-2-(pyrrolidin-1-yl)pyrimido[4,5-b][1,4]benzothiazine
-
 Glycine max
1.13.11.33 additional information docking experiments and qualitative structure-activity relationship, QSAR, data, overview Glycine max

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.33 arachidonate + O2 Glycine max
-
 (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.33 Glycine max
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.33 arachidonate + O2
-
 Glycine max (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
1.13.11.33 linoleic acid + O2
-
 Glycine max ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.33 15-lipoxygenase
-
 Glycine max
1.13.11.33 15-LO
-
 Glycine max
1.13.11.33 More cf. EC 1.13.11.12 Glycine max

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.13.11.33 20
-
 assay at Glycine max

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.13.11.33 9
-
 assay at Glycine max

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.33 0.018
-
 pH 9.0, 20°C Glycine max 4-methyl-2-(4-methylpiperazin-1-yl)pyrimido[4,5-b][1,4]benzothiazine
1.13.11.33 0.034
-
 pH 9.0, 20°C Glycine max 2-(4-ethylpiperazin-1-yl)4-methylpyrimido[4,5-b][1,4]benzothiazine
1.13.11.33 0.048
-
 pH 9.0, 20°C Glycine max 4-methyl-2-(pyrrolidin-1-yl)pyrimido[4,5-b][1,4]benzothiazine
1.13.11.33 0.053
-
 pH 9.0, 20°C Glycine max 4-methyl-2-(morpholin-4-yl)pyrimido[4,5-b][1,4]benzothiazine
1.13.11.33 0.058
-
 pH 9.0, 20°C Glycine max 4-methyl-2-(piperidin-1-yl)pyrimido[4,5-b][1,4]benzothiazine
1.13.11.33 0.076
-
 pH 9.0, 20°C Glycine max 4-methyl-2-(4-methylpiperidin-1-yl)pyrimido[4,5-b][1,4]benzothiazine
1.13.11.33 0.2
-
 above, pH 9.0, 20°C Glycine max 4-methyl-2-(4-hydroxypiperidin-1-yl)pyrimido[4,5-b][1,4]benzothiazine
1.13.11.33 0.2
-
 above, pH 9.0, 20°C Glycine max 4-methyl-2-(4-phenylpiperazin-1-yl)pyrimido[4,5-b][1,4]benzothiazine