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Literature summary extracted from

  • Yamamoto, T.; Eguchi, T.
    Thiahomoisocitrate: a highly potent inhibitor of homoisocitrate dehydrogenase involved in the alpha-aminoadipate pathway (2008), Bioorg. Med. Chem., 16, 3372-3376.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.87 3-[(carboxymethyl)sulfanyl]-2-oxopropanoic acid
-
 Saccharomyces cerevisiae
1.1.1.87 trisodium (2S,3R)-2-(carboxylatomethoxy)-3-hydroxybutanedioate
-
 Saccharomyces cerevisiae
1.1.1.87 trisodium (2S,3R)-2-[(carboxylatomethyl)amino]-3-hydroxybutanedioate
-
 Saccharomyces cerevisiae
1.1.1.87 trisodium (2S,3S)-2-[(carboxylatomethyl)sulfanyl]-3-hydroxybutanedioate
-
 Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.87 0.018
-
 homoisocitrate
-
 Saccharomyces cerevisiae
1.1.1.87 0.02
-
 trisodium (2S,3R)-2-(carboxylatomethoxy)-3-hydroxybutanedioate
-
 Saccharomyces cerevisiae
1.1.1.87 0.15
-
 trisodium (2S,3R)-2-[(carboxylatomethyl)amino]-3-hydroxybutanedioate
-
 Saccharomyces cerevisiae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.87 Mg2+
-
 Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.87 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.87 homoisocitrate + NAD+
-
 Saccharomyces cerevisiae alpha-ketoadipate + NADH + CO2
-
 r
1.1.1.87 trisodium (2S,3R)-2-(carboxylatomethoxy)-3-hydroxybutanedioate + NAD+
-
 Saccharomyces cerevisiae ? + NADH + CO2
-
 ?
1.1.1.87 trisodium (2S,3R)-2-[(carboxylatomethyl)amino]-3-hydroxybutanedioate + NAD+
-
 Saccharomyces cerevisiae ? + NADH + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.87 homoisocitrate dehydrogenase
-
 Saccharomyces cerevisiae
1.1.1.87 ScHICDH
-
 Saccharomyces cerevisiae

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.87 0.59
-
 trisodium (2S,3R)-2-(carboxylatomethoxy)-3-hydroxybutanedioate
-
 Saccharomyces cerevisiae
1.1.1.87 2
-
 trisodium (2S,3R)-2-[(carboxylatomethyl)amino]-3-hydroxybutanedioate
-
 Saccharomyces cerevisiae
1.1.1.87 17
-
 homoisocitrate
-
 Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.87 7.8
-
 assay at Saccharomyces cerevisiae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.87 0.000097
-
 trisodium (2S,3S)-2-[(carboxylatomethyl)sulfanyl]-3-hydroxybutanedioate
-
 Saccharomyces cerevisiae
1.1.1.87 0.01
-
 trisodium (2S,3R)-2-(carboxylatomethoxy)-3-hydroxybutanedioate
-
 Saccharomyces cerevisiae
1.1.1.87 12
-
 3-[(carboxymethyl)sulfanyl]-2-oxopropanoic acid
-
 Saccharomyces cerevisiae