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Literature summary extracted from

  • Liu, X.; Chen, R.; Shang, Y.; Jiao, B.; Huang, C.
    Lithospermic acid as a novel xanthine oxidase inhibitor has anti-inflammatory and hypouricemic effects in rats (2008), Chem. Biol. Interact., 176, 137-142.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.3.2 lithospermic acid isolated from roots of medicinal herb Salvia mitiorrhiza, the compound shows competitive enzyme inhibition activity and in vivo hypouricemic and anti-inflammatory effects in rats pretreated with uricase inhibitor potassium oxonate, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.3.2 xanthine + H2O + O2 Rattus norvegicus production of superoxide radicals urate + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.3.2 neutrophil
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.17.3.2 additional information
-
 measurement of reactive oxygen species production by human neutrophils Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.3.2 xanthine + H2O + O2 production of superoxide radicals Rattus norvegicus urate + H2O2
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.17.3.2 7.5
-
 assay at Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.17.3.2 additional information
-
 IC50 of lithopsermic acid is 0.0052 mg/ml Rattus norvegicus additional information