Literature summary extracted from

Sadahiro, S.; Suzuki, T.; Maeda, Y.; Ishikawa, K.; Tanaka, Y.; Yasuda, S.; Kamijo, A.; Makuuchi, H.; Murayama, C.
Dihydropyrimidine dehydrogenase activity during long-term adjuvant treatment with oral uracil and tegafur for colorectal cancer (2007), Chemotherapy, 53, 442-445.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.3.1.1	additional information	combined oral treatment with uracil and tegafur has no influence on DPD activity	Homo sapiens
1.3.1.1	Uracil	reversible inhibition	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.3.1.1	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.3.1.1	peripheral blood mononuclear cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.3.1.1	5-fluorouracil + NAD+	-	Homo sapiens	alpha-fluoro-beta-alanine + NADH + H+	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.3.1.1	dihydropyrimidine dehydrogenase	-	Homo sapiens
1.3.1.1	DPD	-	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.3.1.1	NAD+	-	Homo sapiens

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Release 2023.1 (January 2023)