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Literature summary extracted from
- Anti-Muellerian hormone and 11 beta-hydroxylase show reciprocal expression to that of aromatase in the transforming gonad of zebrafish males (2007), Dev. Dyn., 236, 1329-1338.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.15.4 | additional information | genes amh and cyp11b are both upregulated during juvenile ovary-to-testis transformation | Danio rerio |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.15.4 | gene cyp11b, sequence comparison and expression analysis | Danio rerio |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.15.4 | additional information | Danio rerio | the enzyme is involved in gonadal transformation in the zebrafish, enzyme expression regulation, overview | ? | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.15.4 | Danio rerio | A1XRK1 | gene cyp11b, a protogynous hermaphroditic fish | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.15.4 | brain | - |
Danio rerio | - |
| 1.14.15.4 | eye | - |
Danio rerio | - |
| 1.14.15.4 | gonad | during development all zebrafish males first develop a juvenile ovary, that later degenerates and transforms into a testis, the enzyme is involved, but not inducing, in gonadal transformation in the zebrafish, but its localization is not related to the position of degenerating oocytes, overview | Danio rerio | - |
| 1.14.15.4 | gut | - |
Danio rerio | - |
| 1.14.15.4 | heart | - |
Danio rerio | - |
| 1.14.15.4 | kidney | - |
Danio rerio | - |
| 1.14.15.4 | liver | - |
Danio rerio | - |
| 1.14.15.4 | additional information | the mRNA of cyp11b is detected in all the adult organs tested | Danio rerio | - |
| 1.14.15.4 | muscle | higher enzyme expression level | Danio rerio | - |
| 1.14.15.4 | ovary | - |
Danio rerio | - |
| 1.14.15.4 | skin | - |
Danio rerio | - |
| 1.14.15.4 | testis | very high expression level | Danio rerio | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.15.4 | corticosterone + reduced adrenal ferredoxin + O2 | - |
Danio rerio | 11-deoxycorticosterone + adrenal ferredoxin + ? | - |
? | |
| 1.14.15.4 | additional information | the enzyme is involved in gonadal transformation in the zebrafish, enzyme expression regulation, overview | Danio rerio | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.15.4 | 11 beta-hydroxylase | - |
Danio rerio |
| 1.14.15.4 | cyp11beta | - |
Danio rerio |
| 1.14.15.4 | P45011beta | - |
Danio rerio |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.15.4 | reduced adrenal ferredoxin | - |
Danio rerio | |
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Release 2023.1 (January 2023)
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