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Literature summary extracted from
- Roles of heme oxygenase-1 in curcumin-induced growth inhibition in rat smooth muscle cells (2007), Exp. Mol. Med., 39, 267-277.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.18 | additional information | curcumin, but not its metabolite tetrahydrocurcumin, induces HO-1 expression and growth inhibition of aortic smooth muscle cells through Nrf2-dependent antioxidant response element, ARE, activation, mechanism, overview, curcumin is isolated from the rhizomes of turmeric | Homo sapiens | |
| 1.14.14.18 | additional information | curcumin, but not its metabolite tetrahydrocurcumin, induces HO-1 expression and growth inhibition of vascular smooth muscle cells through Nrf2-dependent antioxidant response element, ARE, activation, mechanism, overview, curcumin is isolated from the rhizomes of turmeric | Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.18 | tin protoporphyrin | - |
Homo sapiens |  |
| 1.14.14.18 | tin protoporphyrin | - |
Rattus norvegicus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.18 | Mg2+ | - |
Homo sapiens | |
| 1.14.14.18 | Mg2+ | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.18 | heme + AH2 + O2 | Homo sapiens | in aortic smooth muscle cells, induction of HO-1 confers vascular protection against cellular proliferation mainly via its up-regulation of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 that is involved in negative regulation of cellular proliferation, overview | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
| 1.14.14.18 | heme + AH2 + O2 | Rattus norvegicus | in vascular smooth muscle cells, induction of HO-1 confers vascular protection against cellular proliferation mainly via its up-regulation of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 that is involved in negative regulation of cellular proliferation, overview | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.18 | Homo sapiens | P09601 | - |
- |
| 1.14.14.18 | Rattus norvegicus | P06762 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.18 | aortic smooth muscle cell | - |
Homo sapiens | - |
| 1.14.14.18 | vascular smooth muscle cell | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.18 | heme + AH2 + O2 | - |
Homo sapiens | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
| 1.14.14.18 | heme + AH2 + O2 | - |
Rattus norvegicus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
| 1.14.14.18 | heme + AH2 + O2 | in aortic smooth muscle cells, induction of HO-1 confers vascular protection against cellular proliferation mainly via its up-regulation of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 that is involved in negative regulation of cellular proliferation, overview | Homo sapiens | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
| 1.14.14.18 | heme + AH2 + O2 | in vascular smooth muscle cells, induction of HO-1 confers vascular protection against cellular proliferation mainly via its up-regulation of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 that is involved in negative regulation of cellular proliferation, overview | Rattus norvegicus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.14.18 | heme oxygenase-1 | - |
Homo sapiens |
| 1.14.14.18 | heme oxygenase-1 | - |
Rattus norvegicus |
| 1.14.14.18 | HO-1 | - |
Homo sapiens |
| 1.14.14.18 | HO-1 | - |
Rattus norvegicus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.18 | 37 | - |
assay at | Homo sapiens |
| 1.14.14.18 | 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.18 | 7.4 | - |
assay at | Homo sapiens |
| 1.14.14.18 | 7.4 | - |
assay at | Rattus norvegicus |
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