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Literature summary extracted from

  • Resnick, A.C.; Saiardi, A.
    Inositol polyphosphate multikinase: metabolic architect of nuclear inositides (2008), Front. Biosci., 13, 856-866.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.1.151 medicine putative treatment of cancer Drosophila melanogaster
2.7.1.151 medicine putative treatment of cancer Homo sapiens
2.7.1.151 medicine putative treatment of cancer Rattus norvegicus
2.7.1.151 medicine putative treatment of cancer Saccharomyces cerevisiae
2.7.1.151 medicine putative treatment of cancer Solanum tuberosum
2.7.1.151 medicine putative treatment of cancer Arabidopsis thaliana

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.151 Examinations of plants deficient in IPMK suggest roles in pollen germination, root growth, as well axillary shoot branching. Solanum tuberosum
2.7.1.151 IPMK knockout mice demonstrates the critical roles of IPMK in embryogenesis and central nevous system development. Deletion of IPMK in mice results in early lethality. Homo sapiens
2.7.1.151 IPMK knockout mice demonstrates the critical roles of IPMK in embryogenesis and central nevous system development. Deletion of IPMK in mice results in early lethality. Rattus norvegicus
2.7.1.151 Observed derepression and constitutive elevated levels levels of the transcripts in IPMK mutant yeast but not in ipk1- or ipk6-deficient yeasts confirms the requirement of IPMK in the transcriptional regulation of arginine anabolism and catabolism. Saccharomyces cerevisiae
2.7.1.151 While wild-type yeast displays sequential phosphorylation of Ins(1,4,5)P3 to Ins6, mutation of locus termed GSL3 resulted in the loss of Ins(1,4,5)P3-initiated higher isnositol polyphosphate metabolism. IPMK is identified as GSL3 (Ipk2) and confirmed its requirement for mRNA export. Saccharomyces cerevisiae

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.1.151 Structure database comparisons of the recently solved crystal strucures of Ins(1,4,5)P3-kinase and IPMK confirm the close structural relationship to the lipid inositol kinases despite little primary amino acid sequence similarities. Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.151 additional information IPMK3s phosphoinositide-3 kinase activity is distinguished from previously described phosphoinositide-3 kinase in its complete insensitivity to pharmacological inhibition by wortmannin, a potent inhibitor of canonical phosphoinositide-3 kinase.; selective hypersensitivity to rapamycin, an inhibitor of the TOP (target of rapamycin) kinases wit preeminent regulatory roles in general nitrogencatabolite repression control. Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.151 nucleus
-
 Drosophila melanogaster 5634
-
2.7.1.151 nucleus
-
 Homo sapiens 5634
-
2.7.1.151 nucleus
-
 Rattus norvegicus 5634
-
2.7.1.151 nucleus
-
 Saccharomyces cerevisiae 5634
-
2.7.1.151 nucleus
-
 Solanum tuberosum 5634
-
2.7.1.151 nucleus
-
 Arabidopsis thaliana 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.151 2 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,4,5,6-tetrakisphosphate Drosophila melanogaster
-
 2 ADP + 2 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 2 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,4,5,6-tetrakisphosphate Arabidopsis thaliana
-
 2 ADP + 2 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 2 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,4,5,6-tetrakisphosphate Homo sapiens in rats and humans 2 ADP + 2 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 2 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,4,5,6-tetrakisphosphate Rattus norvegicus in rats and humans 2 ADP + 2 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 2 ATP + 1D-myo-inositol 1,4,5-trisphosphate Homo sapiens
-
 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 r
2.7.1.151 2 ATP + 1D-myo-inositol 4,5-bisphosphate Rattus norvegicus
-
 2 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.151 3 ATP + 2 1D-myo-inositol 1,4,5-trisphosphate Drosophila melanogaster
-
 3 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 3 ATP + 2 1D-myo-inositol 1,4,5-trisphosphate Arabidopsis thaliana
-
 3 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 3 ATP + 2 1D-myo-inositol 1,4,5-trisphosphate Homo sapiens in rats and humans 3 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 3 ATP + 2 1D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus in rats and humans 3 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,2,3,4,6-pentakisphosphate Arabidopsis thaliana
-
 ADP + inositol hexakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate Homo sapiens
-
 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate Arabidopsis thaliana
-
 ADP + ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 r
2.7.1.151 ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate Homo sapiens
-
 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,4,5-trisphosphate Saccharomyces cerevisiae
-
 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 r
2.7.1.151 ATP + phosphatidylinositol 4,5-bisphosphate Rattus norvegicus in rats ADP + phosphatidylinositol 3,4,5-trisphosphate
-
 ?
2.7.1.151 ATP + phosphatidylinositol 4,5-bisphosphate Solanum tuberosum
-
 ADP + phosphatidylinositol (3,4,5)-trisphosphate
-
 ?
2.7.1.151 additional information Drosophila melanogaster Genome-wide RNA interference screen in cultured Drosophila melanogaster haemocyte-like cells identifies as a regulator of the Janus tyrosine kinase/signal transducer and activator of transcription. ?
-
 ?
2.7.1.151 additional information Homo sapiens role in chromatin remodelling ?
-
 ?
2.7.1.151 additional information Rattus norvegicus role in chromatin remodelling ?
-
 ?
2.7.1.151 additional information Homo sapiens Studies in the rat cells and mice suggest that Ins(1,4,5)P3 3-kinases likely contribute little to the synthesis of inositol pentakisphosphate and inositol hexakisphosphate ?
-
 ?
2.7.1.151 additional information Rattus norvegicus Studies in the rat cells and mice suggest that Ins(1,4,5)P3 3-kinases likely contribute little to the synthesis of InsP5 and InsP6 ?
-
 ?
2.7.1.151 additional information Homo sapiens The 3-step pathway to InsP6 mediated by phospholipase C, IPMK and inositol kinase (Ipk1) in yeast contrasts with an alternative description of a 5-step pathway in human cells. ?
-
 ?
2.7.1.151 additional information Rattus norvegicus The 3-step pathway to InsP6 mediated by phospholipase C, IPMK and inositol kinase (Ipk1) in yeast contrasts with an alternative description of a 5-step pathway in human cells. ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.151 Arabidopsis thaliana
-
 Like the yeast enzyme, mammalian, plant and fly orthologs share the capacity for the conversion of Ins(1,4,5)P3 to Ins(1,3,4,5,6)P5. Plant and fly IPMKs recapitulate the yeast enzyme's preference for D6-hydroxyl phoshorylation followed by D3-hydroxylphosphorylation, mammalian IPMKs appear to prefer the reverse order.
-
2.7.1.151 Drosophila melanogaster
-
 Like the yeast enzyme, mammalian, plant and fly orthologs share the capacity for the conversion of Ins(1,4,5)P3 to Ins(1,3,4,5,6)P5. Plant and fly IPMKs recapitulate the yeast enzyme's preference for D6-hydroxyl phoshorylation followed by D3-hydroxylphosphorylation, mammalian IPMKs appear to prefer the reverse order.
-
2.7.1.151 Homo sapiens
-
 Like the yeast enzyme, mammalian, plant and fly orthologs share the capacity for the conversion of Ins(1,4,5)P3 to Ins(1,3,4,5,6)P5. Plant and fly IPMKs recapitulate the yeast enzyme's preference for D6-hydroxyl phoshorylation followed by D3-hydroxylphosphorylation, mammalian IPMKs appear to prefer the reverse order.
-
2.7.1.151 Rattus norvegicus
-
 Like the yeast enzyme, mammalian, plant and fly orthologs share the capacity for the conversion of Ins(1,4,5)P3 to Ins(1,3,4,5,6)P5. Plant and fly IPMKs recapitulate the yeast enzyme's preference for D6-hydroxyl phoshorylation followed by D3-hydroxylphosphorylation, mammalian IPMKs appear to prefer the reverse order.
-
2.7.1.151 Saccharomyces cerevisiae
-
 Like the yeast enzyme, mammalian, plant and fly orthologs share the capacity for the conversion of Ins(1,4,5)P3 to Ins(1,3,4,5,6)P5. Plant and fly IPMKs recapitulate the yeast enzyme's preference for D6-hydroxyl phoshorylation followed by D3-hydroxylphosphorylation, mammalian IPMKs appear to prefer the reverse order.
-
2.7.1.151 Solanum tuberosum
-
 Like the yeast enzyme, mammalian, plant and fly orthologs share the capacity for the conversion of Ins(1,4,5)P3 to Ins(1,3,4,5,6)P5. Plant and fly IPMKs recapitulate the yeast enzyme's preference for D6-hydroxyl phoshorylation followed by D3-hydroxylphosphorylation, mammalian IPMKs appear to prefer the reverse order.
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.151 phosphoprotein
-
 Drosophila melanogaster
2.7.1.151 phosphoprotein
-
 Homo sapiens
2.7.1.151 phosphoprotein
-
 Rattus norvegicus
2.7.1.151 phosphoprotein
-
 Saccharomyces cerevisiae
2.7.1.151 phosphoprotein
-
 Solanum tuberosum
2.7.1.151 phosphoprotein
-
 Arabidopsis thaliana

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.151 additional information
-
 water-soluble kinase activity and phosphoinositide kinase activity Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.151 2 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
 Drosophila melanogaster 2 ADP + 2 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 2 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
 Arabidopsis thaliana 2 ADP + 2 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 2 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,4,5,6-tetrakisphosphate in rats and humans Homo sapiens 2 ADP + 2 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 2 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,4,5,6-tetrakisphosphate in rats and humans Rattus norvegicus 2 ADP + 2 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 2 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Homo sapiens 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 r
2.7.1.151 2 ATP + 1D-myo-inositol 4,5-bisphosphate
-
 Rattus norvegicus 2 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.151 3 ATP + 2 1D-myo-inositol 1,4,5-trisphosphate
-
 Drosophila melanogaster 3 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 3 ATP + 2 1D-myo-inositol 1,4,5-trisphosphate
-
 Arabidopsis thaliana 3 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 3 ATP + 2 1D-myo-inositol 1,4,5-trisphosphate in rats and humans Homo sapiens 3 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 3 ATP + 2 1D-myo-inositol 1,4,5-trisphosphate in rats and humans Rattus norvegicus 3 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,2,3,4,6-pentakisphosphate
-
 Arabidopsis thaliana ADP + inositol hexakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
-
 Arabidopsis thaliana ADP + ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 r
2.7.1.151 ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Saccharomyces cerevisiae ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 r
2.7.1.151 ATP + phosphatidylinositol 4,5-bisphosphate in rats Rattus norvegicus ADP + phosphatidylinositol 3,4,5-trisphosphate
-
 ?
2.7.1.151 ATP + phosphatidylinositol 4,5-bisphosphate
-
 Solanum tuberosum ADP + phosphatidylinositol (3,4,5)-trisphosphate
-
 ?
2.7.1.151 additional information Genome-wide RNA interference screen in cultured Drosophila melanogaster haemocyte-like cells identifies as a regulator of the Janus tyrosine kinase/signal transducer and activator of transcription. Drosophila melanogaster ?
-
 ?
2.7.1.151 additional information role in chromatin remodelling Homo sapiens ?
-
 ?
2.7.1.151 additional information role in chromatin remodelling Rattus norvegicus ?
-
 ?
2.7.1.151 additional information Studies in the rat cells and mice suggest that Ins(1,4,5)P3 3-kinases likely contribute little to the synthesis of inositol pentakisphosphate and inositol hexakisphosphate Homo sapiens ?
-
 ?
2.7.1.151 additional information Studies in the rat cells and mice suggest that Ins(1,4,5)P3 3-kinases likely contribute little to the synthesis of InsP5 and InsP6 Rattus norvegicus ?
-
 ?
2.7.1.151 additional information The 3-step pathway to InsP6 mediated by phospholipase C, IPMK and inositol kinase (Ipk1) in yeast contrasts with an alternative description of a 5-step pathway in human cells. Homo sapiens ?
-
 ?
2.7.1.151 additional information The 3-step pathway to InsP6 mediated by phospholipase C, IPMK and inositol kinase (Ipk1) in yeast contrasts with an alternative description of a 5-step pathway in human cells. Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.151 Arg82 enzyme is an arginine-sensitive nuclear transcription factor Saccharomyces cerevisiae
2.7.1.151 ARGSIII
-
 Saccharomyces cerevisiae
2.7.1.151 AtIpk2a
-
 Arabidopsis thaliana
2.7.1.151 AtIpk2b
-
 Arabidopsis thaliana
2.7.1.151 Ins(1,4,5)P3 3-kinase
-
 Homo sapiens
2.7.1.151 Ins(1,4,5)P3 3-kinase
-
 Rattus norvegicus
2.7.1.151 InsP4 5-kinase in humans Homo sapiens
2.7.1.151 Ipk2
-
 Drosophila melanogaster
2.7.1.151 Ipk2
-
 Saccharomyces cerevisiae
2.7.1.151 IPKII
-
 Saccharomyces cerevisiae
2.7.1.151 IPMK
-
 Saccharomyces cerevisiae
2.7.1.151 IPMK enzyme phosphorylates sequentially inositol trisphosphate to inositol heakisphosphate Solanum tuberosum
2.7.1.151 IPMK enzyme phosphorylates sequentially inositol trisphosphate to inositol hexakisphosphate Homo sapiens
2.7.1.151 IPMK enzyme phosphorylates sequentially InsP3 to InsP6 Rattus norvegicus
2.7.1.151 PI3K non-canonical Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.151 ATP
-
 Drosophila melanogaster
2.7.1.151 ATP
-
 Homo sapiens
2.7.1.151 ATP
-
 Rattus norvegicus
2.7.1.151 ATP
-
 Saccharomyces cerevisiae
2.7.1.151 ATP
-
 Solanum tuberosum
2.7.1.151 ATP
-
 Arabidopsis thaliana