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Literature summary extracted from

  • Ohta, T.; Chakrabarty, S.; Lipscomb, J.D.; Solomon, E.I.
    Near-IR MCD of the nonheme ferrous active site in naphthalene 1,2-dioxygenase: correlation to crystallography and structural insight into the mechanism of Rieske dioxygenases (2008), J. Am. Chem. Soc., 130, 1601-1610.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.12.12 Iron the catalytic ferrous site is primed for the O2 reaction when substrate is bound in the active site in the presence of the reduced Rieske site. These structural changes ensure that two electrons and the substrate are present before the binding and activation of O2, which avoids the uncontrolled formation and release of reactive oxygen species Pseudomonas sp.

Organism

EC Number Organism UniProt Comment Textmining
1.14.12.12 Pseudomonas sp.
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 NCIB 9816-4
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.12.12 naphthalene + NADH + H+ + O2 the catalytic ferrous site is primed for the O2 reaction when substrate is bound in the active site in the presence of the reduced Rieske site. These structural changes ensure that two electrons and the substrate are present before the binding and activation of O2, which avoids the uncontrolled formation and release of reactive oxygen species Pseudomonas sp. (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+
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