Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Reddy, C.C.; Pierzchala, P.A.; Hamilton, G.A.
    myo-Inositol oxygenase from hog kidney. II. Catalytic properties of the homogeneous enzyme (1981), J. Biol. Chem., 256, 8519-8524.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.99.1 cysteine best activation system: 1 mM Fe(II) and 2 mM cysteine Sus scrofa
1.13.99.1 cysteine DL-penicillamine Sus scrofa
1.13.99.1 cysteine either reagent alone gives very little activation Sus scrofa
1.13.99.1 cysteine L-cysteine can be replaced by D-cysteine Sus scrofa
1.13.99.1 cysteine or gamma-L-glutamyl-L-cysteine Sus scrofa
1.13.99.1 D-cysteine best activation system: 1 mM Fe(II) and 2 mM cysteine, L-cysteine can be replaced by D-cysteine, DL-penicillamine or gamma-L-glutamyl-L-cysteine Sus scrofa
1.13.99.1 DL-Penicillamine best activation system: 1 mM Fe(II) and 2 mM cysteine, L-cysteine can be replaced by D-cysteine, DL-penicillamine or gamma-L-glutamyl-L-cysteine Sus scrofa
1.13.99.1 gamma-L-glutamyl-L-cysteine best activation system: 1 mM Fe(II) and 2 mM cysteine, L-cysteine can be replaced by D-cysteine, DL-penicillamine or gamma-L-glutamyl-L-cysteine Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.99.1 5,5'-dithiobis(2-nitrobenzoate)
-
Sus scrofa
1.13.99.1 8-hydroxyquinoline
-
Sus scrofa
1.13.99.1 ADP
-
Sus scrofa
1.13.99.1 alpha,alpha'-bipyridine
-
Sus scrofa
1.13.99.1 alpha-ketoglutarate
-
Sus scrofa
1.13.99.1 ATP
-
Sus scrofa
1.13.99.1 azide
-
Sus scrofa
1.13.99.1 Barbital
-
Sus scrofa
1.13.99.1 Cu2+
-
Sus scrofa
1.13.99.1 cyanide
-
Sus scrofa
1.13.99.1 diethyldithiocarbamate
-
Sus scrofa
1.13.99.1 EDTA
-
Sus scrofa
1.13.99.1 Fe3+
-
Sus scrofa
1.13.99.1 ferricyanide
-
Sus scrofa
1.13.99.1 ferrocyanide
-
Sus scrofa
1.13.99.1 glyoxylate
-
Sus scrofa
1.13.99.1 GTP
-
Sus scrofa
1.13.99.1 H2O2
-
Sus scrofa
1.13.99.1 Hg2+
-
Sus scrofa
1.13.99.1 iodoacetate
-
Sus scrofa
1.13.99.1 N-ethylmaleimide slight Sus scrofa
1.13.99.1 o-phenanthroline
-
Sus scrofa
1.13.99.1 oxalacetate
-
Sus scrofa
1.13.99.1 oxalate
-
Sus scrofa
1.13.99.1 p-chloromercuribenzoate
-
Sus scrofa
1.13.99.1 Phenobarbital
-
Sus scrofa
1.13.99.1 pyruvate
-
Sus scrofa
1.13.99.1 Sodium borohydride
-
Sus scrofa
1.13.99.1 UDP
-
Sus scrofa
1.13.99.1 UTP
-
Sus scrofa
1.13.99.1 xanthurenic acid
-
Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.99.1 0.2
-
Inositol with Fe(II) and quinolinic acid as activators Sus scrofa
1.13.99.1 5
-
Inositol with Fe(II) and L-cysteine as activators Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.99.1 Fe2+ either reagent alone gives very little activation Sus scrofa
1.13.99.1 Fe2+ no other metal ion can replace Fe(II) Sus scrofa
1.13.99.1 Fe2+ 1 mM Fe(II) and 2 mM cysteine Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.13.99.1 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.99.1 kidney
-
Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.99.1 myo-inositol + O2 highly specific for myo-inositol Sus scrofa D-glucuronate + H2O
-
?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.13.99.1 34
-
inactivation during 15 min assay Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.13.99.1 6
-
-
Sus scrofa