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Literature summary extracted from
- Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress (2007), J. Biol. Chem., 282, 20621-20633.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.14.18 | DNA and amino acid sequence determination of wild-type and mutant, full-length and truncated enzymes, expression of the N-terminus of the rat enzyme in human HEK-293 cells, and of FLAG-tagged inactive mutant H25A in 3T3 cells, nuclear translocation of enzyme mutants lacking the C-terminus and of mutant H25A, overview | Rattus norvegicus |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.14.14.18 | H25A | site-directed mutagenesis, the mutant is translocated to the nucleus losing its C-terminus | Rattus norvegicus |
| 1.14.14.18 | additional information | HO-1 overexpression activates an oxidant-responsive HO-1 promoter | Rattus norvegicus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.14.18 | additional information | effect of nuclear localization of HO-1oncell viability | Rattus norvegicus | - |
- |
| 1.14.14.18 | nucleus | in response to different stimuli, e.g. hypoxia by 3% oxygen or incubation with hemin or heme-hemopexin, HO-1 can migrate to the nucleus. Nuclear translocation is associated with truncation of the C-terminus of HO-1 | Mus musculus | 5634 | - |
| 1.14.14.18 | nucleus | in response to different stimuli, e.g. hypoxia by 3% oxygen or incubation with hemin or heme-hemopexin, HO-1 can migrate to the nucleus. Nuclear translocation is associated with truncation of the C-terminus of HO-1 by 52 amino acids, the C-terminal region of HO-1 inhibits the nuclear import | Rattus norvegicus | 5634 | - |
| 1.14.14.18 | smooth endoplasmic reticulum | full-length HO-1 is an integral membrane protein | Mus musculus | 5790 | - |
| 1.14.14.18 | smooth endoplasmic reticulum | full-length HO-1 is an integral membrane protein | Rattus norvegicus | 5790 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.18 | heme + AH2 + O2 | Mus musculus | HO-1 is the rate-limiting enzyme in heme degradation | biliverdin + Fe2+ + CO + A + H2O | - |
? |  |
| 1.14.14.18 | heme + AH2 + O2 | Rattus norvegicus | HO-1 is the rate-limiting enzyme in heme degradation | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
| 1.14.14.18 | additional information | Rattus norvegicus | HO-1 protein delivery mediates activation of various transcription factors, nuclear localization of HO-1 has a signalling role, effect of nuclear localization of HO-1oncell viability, overview | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.18 | Mus musculus | - |
- |
- |
| 1.14.14.18 | Rattus norvegicus | P06762 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.18 | fibroblast | - |
Mus musculus | - |
| 1.14.14.18 | NIH-3T3 cell | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.18 | additional information | - |
transcription factor activation activity of recombinant wild-type and mutant enzymes, overview | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.18 | heme + AH2 + O2 | - |
Mus musculus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
| 1.14.14.18 | heme + AH2 + O2 | - |
Rattus norvegicus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
| 1.14.14.18 | heme + AH2 + O2 | HO-1 is the rate-limiting enzyme in heme degradation | Mus musculus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
| 1.14.14.18 | heme + AH2 + O2 | HO-1 is the rate-limiting enzyme in heme degradation | Rattus norvegicus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
| 1.14.14.18 | additional information | HO-1 protein delivery mediates activation of various transcription factors, nuclear localization of HO-1 has a signalling role, effect of nuclear localization of HO-1oncell viability, overview | Rattus norvegicus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.14.18 | heme oxygenase-1 | - |
Mus musculus |
| 1.14.14.18 | heme oxygenase-1 | - |
Rattus norvegicus |
| 1.14.14.18 | HO-1 | - |
Mus musculus |
| 1.14.14.18 | HO-1 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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