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Literature summary extracted from

  • Khobragade, C.N.; Bodade, R.G.; Shinde, M.S.; Jaju, D.R.; Bhosle, R.B.; Dawane, B.S.
    Microbial and xanthine dehydrogenase inhibitory activity of some flavones (2008), J. Enzyme Inhib. Med. Chem., 23, 341-346.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.1.4 6-chloro-2-[3-(4-hydroxyphenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Microsporum cannis, Serratia marcescens, Staphylococcus aureus Fusarium verticillioides
1.17.1.4 6-chloro-2-[3-(4-hydroxyphenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one noncompetitive, Ki-value 0.0011 mg/ml Gallus gallus
1.17.1.4 6-chloro-2-[3-(4-hydroxyphenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Microsporum cannis, Serratia marcescens, Staphylococcus aureus Microsporum canis
1.17.1.4 6-chloro-2-[3-(4-hydroxyphenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Microsporum cannis, Serratia marcescens, Staphylococcus aureus Penicillium chrysogenum
1.17.1.4 6-chloro-2-[3-(4-hydroxyphenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Micrnosporum cannis, Serratia marcescens, Staphylococcus aureus Serratia marcescens
1.17.1.4 6-chloro-2-[3-(4-hydroxyphenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Microsporum cannis, Serratia marcescens, Staphylococcus aureus Staphylococcus aureus
1.17.1.4 6-chloro-2-[3-(4-hydroxyphenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Microsporum cannis, Serratia marcescens, Staphylococcus aureus Trichoderma viride
1.17.1.4 6-chloro-7-methyl-2-[3-(4-chlorophenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Microsporum cannis, Serratia marcescens, Staphylococcus aureus Fusarium verticillioides
1.17.1.4 6-chloro-7-methyl-2-[3-(4-chlorophenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one competitive, Ki-value 0.00022 mg/ml Gallus gallus
1.17.1.4 6-chloro-7-methyl-2-[3-(4-chlorophenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Microsporum cannis, Serratia marcescens, Staphylococcus aureus Microsporum canis
1.17.1.4 6-chloro-7-methyl-2-[3-(4-chlorophenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Microsporum cannis, Serratia marcescens, Staphylococcus aureus Penicillium chrysogenum
1.17.1.4 6-chloro-7-methyl-2-[3-(4-chlorophenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Microsporum cannis, Serratia marcescens, Staphylococcus aureus Serratia marcescens
1.17.1.4 6-chloro-7-methyl-2-[3-(4-chlorophenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Microsporum cannis, Serratia marcescens, Staphylococcus aureus Staphylococcus aureus
1.17.1.4 6-chloro-7-methyl-2-[3-(4-chlorophenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Microsporum cannis, Serratia marcescens, Staphylococcus aureus Trichoderma viride

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.17.1.4 additional information
-
 additional information Km-value is 0.0025 mg/ml xanthine Gallus gallus
1.17.1.4 additional information
-
 additional information Km-value is 0.0025 mg/ml xanthine Staphylococcus aureus
1.17.1.4 additional information
-
 additional information Km-value is 0.0025 mg/ml xanthine Penicillium chrysogenum
1.17.1.4 additional information
-
 additional information Km-value is 0.0025 mg/ml xanthine Serratia marcescens
1.17.1.4 additional information
-
 additional information Km-value is 0.0025 mg/ml xanthine Trichoderma viride
1.17.1.4 additional information
-
 additional information Km-value is 0.0025 mg/ml xanthine Fusarium verticillioides
1.17.1.4 additional information
-
 additional information Km-value is 0.0025 mg/ml xanthine Microsporum canis

Organism

EC Number Organism UniProt Comment Textmining
1.17.1.4 Fusarium verticillioides
-
-
-
1.17.1.4 Gallus gallus
-
-
-
1.17.1.4 Microsporum canis
-
-
-
1.17.1.4 Penicillium chrysogenum
-
-
-
1.17.1.4 Serratia marcescens
-
-
-
1.17.1.4 Staphylococcus aureus
-
-
-
1.17.1.4 Trichoderma viride
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.1.4 liver
-
 Gallus gallus
-
1.17.1.4 liver
-
 Staphylococcus aureus
-
1.17.1.4 liver
-
 Penicillium chrysogenum
-
1.17.1.4 liver
-
 Serratia marcescens
-
1.17.1.4 liver
-
 Trichoderma viride
-
1.17.1.4 liver
-
 Fusarium verticillioides
-
1.17.1.4 liver
-
 Microsporum canis
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.17.1.4 0.22
-
 pH 7.5, 37°C Gallus gallus
1.17.1.4 0.22
-
 pH 7.5, 37°C Staphylococcus aureus
1.17.1.4 0.22
-
 pH 7.5, 37°C Penicillium chrysogenum
1.17.1.4 0.22
-
 pH 7.5, 37°C Serratia marcescens
1.17.1.4 0.22
-
 pH 7.5, 37°C Trichoderma viride
1.17.1.4 0.22
-
 pH 7.5, 37°C Fusarium verticillioides
1.17.1.4 0.22
-
 pH 7.5, 37°C Microsporum canis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.1.4 xanthine + NAD+ + H2O
-
 Gallus gallus urate + NADH
-
 ?
1.17.1.4 xanthine + NAD+ + H2O
-
 Staphylococcus aureus urate + NADH
-
 ?
1.17.1.4 xanthine + NAD+ + H2O
-
 Penicillium chrysogenum urate + NADH
-
 ?
1.17.1.4 xanthine + NAD+ + H2O
-
 Serratia marcescens urate + NADH
-
 ?
1.17.1.4 xanthine + NAD+ + H2O
-
 Trichoderma viride urate + NADH
-
 ?
1.17.1.4 xanthine + NAD+ + H2O
-
 Fusarium verticillioides urate + NADH
-
 ?
1.17.1.4 xanthine + NAD+ + H2O
-
 Microsporum canis urate + NADH
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.17.1.4 40
-
-
 Gallus gallus
1.17.1.4 40
-
-
 Staphylococcus aureus
1.17.1.4 40
-
-
 Penicillium chrysogenum
1.17.1.4 40
-
-
 Serratia marcescens
1.17.1.4 40
-
-
 Trichoderma viride
1.17.1.4 40
-
-
 Fusarium verticillioides
1.17.1.4 40
-
-
 Microsporum canis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.17.1.4 7.5
-
-
 Gallus gallus
1.17.1.4 7.5
-
-
 Staphylococcus aureus
1.17.1.4 7.5
-
-
 Penicillium chrysogenum
1.17.1.4 7.5
-
-
 Serratia marcescens
1.17.1.4 7.5
-
-
 Trichoderma viride
1.17.1.4 7.5
-
-
 Fusarium verticillioides
1.17.1.4 7.5
-
-
 Microsporum canis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.17.1.4 additional information
-
 additional information 6-chloro-2-[3-(4-hydroxyphenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one, Ki-value 0.0011 mg/ml, 6-chloro-7-methyl-2-[3-(4-chlorophenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one, Ki-value 0.00022 mg/ml, respectively Gallus gallus