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Literature summary extracted from

  • Mostefai, H.A.; Agouni, A.; Carusio, N.; Mastronardi, M.L.; Heymes, C.; Henrion, D.; Andriantsitohaina, R.; Martinez, M.C.
    Phosphatidylinositol 3-kinase and xanthine oxidase regulate nitric oxide and reactive oxygen species productions by apoptotic lymphocyte microparticles in endothelial cells (2008), J. Immunol., 180, 5028-5035.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.17.3.2 apoptotic lymphocyte microparticles microparticles are membrane vesicles released during cell activation and apoptosis, they activate reactive oxygen species production by xanthine oxidase in endothelial cells and aorta, inhibition of phosphoinositol 3-kinase enhances the activating effect, xanthine oxidase inhibitors reduce it, overview Homo sapiens
2.7.1.137 additional information microparticles, membrane vesicles released during cell activation and apoptosis, activate pathways related to NO and reactive oxygen species productions through PI3K, xanthine oxidase, and NF-kappaB pathways, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.137 LY294002
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.3.2 additional information Homo sapiens phosphatidylinositol 3-kinase and xanthine oxidase regulate nitric oxide and reactive oxygen species productions by apoptotic lymphocyte microparticles in endothelial cells, overview ?
-
 ?
1.17.3.2 xanthine + H2O + O2 Homo sapiens production of reactive oxygen species via superoxide radicals involved in endothelial dysfunction urate + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Homo sapiens
-
-
-
2.7.1.137 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.3.2 aorta
-
 Homo sapiens
-
1.17.3.2 CCRF-CEM cell a lymphoid cell line Homo sapiens
-
1.17.3.2 endothelial cell
-
 Homo sapiens
-
2.7.1.137 endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.3.2 additional information phosphatidylinositol 3-kinase and xanthine oxidase regulate nitric oxide and reactive oxygen species productions by apoptotic lymphocyte microparticles in endothelial cells, overview Homo sapiens ?
-
 ?
1.17.3.2 xanthine + H2O + O2 production of reactive oxygen species via superoxide radicals involved in endothelial dysfunction Homo sapiens urate + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 production of superoxide radicals Homo sapiens urate + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.137 PI3K
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.137 ATP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.137 physiological function phosphatidylinositol 3-kinase and xanthine oxidase regulate nitric oxide and reactive oxygen species productions by apoptotic lymphocyte microparticles in endothelial cells. PI3K inhibition reduces the effects of microparticles on endothelial NO synthase, but not on caveolin-1, whereas it enhances the effects of microparticles on reactive oxygen species production. Microparticles stimulated ERK1/2 phosphorylation via a PI3K-depedent mechanism Homo sapiens