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Literature summary extracted from

  • Marma, M.S.; Xia, Z.; Stewart, C.; Coxon, F.; Dunford, J.E.; Baron, R.; Kashemirov, B.A.; Ebetino, F.H.; Triffitt, J.T.; Russell, R.G.; McKenna, C.E.
    Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate (2007), J. Med. Chem., 50, 5967-5975.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.60 2-bromo-3-(3-pyridinyl)-2-phosphonopropionic acid
-
 Rattus norvegicus
2.5.1.60 2-chloro-3-(3-pyridinyl)-2-phosphonopropionic acid
-
 Rattus norvegicus
2.5.1.60 2-fluoro-3-(3-pyridinyl)-2-phosphonopropionic acid
-
 Rattus norvegicus
2.5.1.60 3-(3-pyridinyl)-2-phosphonopropionic acid
-
 Rattus norvegicus
2.5.1.60 3-pyridinyl ethylidene hydroxyl phosphonocarboxylate previously known as NE10790 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.60 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.60 geranylgeranyl diphosphate + protein-cysteine
-
 Rattus norvegicus S-geranylgeranyl-protein + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.60 Rab geranylgeranyl transferase
-
 Rattus norvegicus
2.5.1.60 RGGT
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.5.1.60 0.0163
-
-
 Rattus norvegicus 2-fluoro-3-(3-pyridinyl)-2-phosphonopropionic acid
2.5.1.60 0.0164
-
-
 Rattus norvegicus 2-chloro-3-(3-pyridinyl)-2-phosphonopropionic acid
2.5.1.60 0.0177
-
-
 Rattus norvegicus 2-bromo-3-(3-pyridinyl)-2-phosphonopropionic acid
2.5.1.60 0.0241
-
-
 Rattus norvegicus 3-pyridinyl ethylidene hydroxyl phosphonocarboxylate
2.5.1.60 0.0353
-
-
 Rattus norvegicus 3-(3-pyridinyl)-2-phosphonopropionic acid