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Literature summary extracted from

  • Sanchez-Lozada, L.G.; Tapia, E.; Soto, V.; Avila-Casado, C.; Franco, M.; Zhao, L.; Johnson, R.J.
    Treatment with the xanthine oxidase inhibitor febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in experimental hyperuricaemia (2008), Nephrol. Dial. Transplant., 23, 1179-1185.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.3.2 allopurinol
-
Rattus norvegicus
1.17.3.2 febuxostat the inhibitor lowers uric acid and alleviates systemic and glomerular hypertension in experimental hyperuricaemia Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.3.2 xanthine + H2O + O2 Rattus norvegicus xanthine oxidase inhibition by febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in hyperuricaemia, experimentally-induced by inhibition of uricase with oxonic acid, overview urate + H2O2
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Rattus norvegicus
-
male sprague-dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.3.2 kidney
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.3.2 xanthine + H2O + O2 production of superoxide radicals Rattus norvegicus urate + H2O2
-
?
1.17.3.2 xanthine + H2O + O2 xanthine oxidase inhibition by febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in hyperuricaemia, experimentally-induced by inhibition of uricase with oxonic acid, overview Rattus norvegicus urate + H2O2
-
?