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Literature summary extracted from

  • Chen, G.L.; Miller, G.M.
    Rhesus monkey tryptophan hydroxylase-2 coding region haplotypes affect mRNA stability (2008), Neuroscience, 155, 485-491.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.16.4 gene TPH2, cloning of four haplotypes of TPH2 into pcDNA3.1 and stable transfected into rat PC-12 cells, transient expressionin HEK-293 cells, quantitative real-time PCR expression analysis and comparison of mRNA stabilities, overview Macaca mulatta

Protein Variants

EC Number Protein Variants Comment Organism
1.14.16.4 additional information C74A and G223A are naturally occuring, nonsynonymous single nucleotide polymorphisms Macaca mulatta

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.16.4 50000
-
 x * 50000, about, recombinant enzyme, SDS-PAGE Macaca mulatta

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.16.4 L-tryptophan + tetrahydrobiopterin + O2 Macaca mulatta the enzyme is involved in neuronal serotonin, i.e. 5-hydroxytryptamine, biosynthesis, genetic variance is associated with numerous behavioral traits and psychiatric disorders 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.4 Macaca mulatta Q2HZ26
-
-
1.14.16.4 no activity in Rattus norvegicus
-
 PC-12 cells
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.4 L-tryptophan + tetrahydrobiopterin + O2
-
 Macaca mulatta 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
1.14.16.4 L-tryptophan + tetrahydrobiopterin + O2 the enzyme is involved in neuronal serotonin, i.e. 5-hydroxytryptamine, biosynthesis, genetic variance is associated with numerous behavioral traits and psychiatric disorders Macaca mulatta 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?

Subunits

EC Number Subunits Comment Organism
1.14.16.4 ? x * 50000, about, recombinant enzyme, SDS-PAGE Macaca mulatta

Synonyms

EC Number Synonyms Comment Organism
1.14.16.4 TPH2
-
 Macaca mulatta
1.14.16.4 tryptophan hydroxylase-2
-
 Macaca mulatta