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Literature summary extracted from

  • van Kuilenburg, A.B.; Meijer, J.; Dobritzsch, D.; Lohkamp, B.; Ruitenbeek, W.; Roelofsen, J.; Abeling, N.G.; Duran, M.; Buzing, C.
    Identification of two novel mutations C79X and R235Q in the dihydropyrimidine dehydrogenase gene in a patient presenting with hematuria (2008), Nucleosides Nucleotides Nucleic Acids, 27, 809-815.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.3.1.2 R235Q the mutation is expected to weaken the binding of the FAD ring system and to change the electronic environment and hence, the redox potential of the cofactor Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.2 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.2 thymine + NADPH + H+
-
 Homo sapiens 5,6-dihydrothymine + NADP+
-
 ?
1.3.1.2 uracil + NADPH + H+
-
 Homo sapiens 5,6-dihydrouracil + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.2 dihydropyrimidine dehydrogenase
-
 Homo sapiens
1.3.1.2 DPD
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.2 NADP+
-
 Homo sapiens