Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Marchitti, S.A.; Deitrich, R.A.; Vasiliou, V.
    Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase (2007), Pharmacol. Rev., 59, 125-150.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.3 Disulfiram 0.01 mM; 0.01 mM; 0.01 mM; 0.01 mM Homo sapiens
1.2.1.5 Disulfiram 0.01 mM; 0.01 mM; 0.01 mM Homo sapiens
1.2.1.18 Disulfiram 0.01 mM Homo sapiens
1.2.1.24 Disulfiram 0.01 mM Homo sapiens
1.2.1.31 Disulfiram 0.01 mM Homo sapiens
1.2.1.36 Disulfiram 0.01 mM Homo sapiens
1.2.1.41 Disulfiram 0.01 mM Homo sapiens
1.2.1.47 Disulfiram 0.01 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.3 0.0004
-
 3,4-dihydroxyphenylacetaldehyde isozyme ALDH1A1 from liver Homo sapiens
1.2.1.3 0.001
-
 3,4-dihydroxyphenylacetaldehyde isozyme ALDH2 from liver Homo sapiens
1.2.1.3 0.0042
-
 3,4-dihydroxyphenylacetaldehyde isozyme ALDH1A1 from brain Homo sapiens
1.2.1.5 0.0004
-
 3,4-dihydroxyphenylacetaldehyde isozyme ALDH1A1 Homo sapiens
1.2.1.5 0.001
-
 3,4-dihydroxyphenylacetaldehyde isozyme ALDH2 from liver Homo sapiens
1.2.1.5 0.0026
-
 3,4-dihydroxyphenylacetaldehyde isozyme ALDH9A1 Homo sapiens
1.2.1.5 0.0042
-
 3,4-dihydroxyphenylacetaldehyde isozyme ALDH1A1 from brain Homo sapiens
1.2.1.5 0.015
-
 3,4-dihydroxyphenylacetaldehyde isozyme ALDH3A1 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.3 cytosol
-
 Homo sapiens 5829
-
1.2.1.3 mitochondrion
-
 Homo sapiens 5739
-
1.2.1.5 cytosol
-
 Homo sapiens 5829
-
1.2.1.5 mitochondrion
-
 Homo sapiens 5739
-
1.2.1.5 nucleus
-
 Homo sapiens 5634
-
1.2.1.18 mitochondrion
-
 Homo sapiens 5739
-
1.2.1.24 mitochondrion
-
 Homo sapiens 5739
-
1.2.1.31 cytosol
-
 Homo sapiens 5829
-
1.2.1.36 cytosol
-
 Homo sapiens 5829
-
1.2.1.41 mitochondrion
-
 Homo sapiens 5739
-
1.2.1.47 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Homo sapiens
-
-
-
1.2.1.3 Homo sapiens P05091
-
-
1.2.1.3 Homo sapiens P30837
-
-
1.2.1.3 Homo sapiens Q9H2A2
-
-
1.2.1.5 Homo sapiens P30838
-
-
1.2.1.5 Homo sapiens P43353
-
-
1.2.1.5 Homo sapiens P47895
-
-
1.2.1.18 Homo sapiens Q02252
-
-
1.2.1.24 Homo sapiens P51649
-
-
1.2.1.31 Homo sapiens P49419
-
-
1.2.1.36 Homo sapiens O94788
-
-
1.2.1.41 Homo sapiens
-
-
-
1.2.1.47 Homo sapiens P49189
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.3 brain
-
 Homo sapiens
-
1.2.1.3 liver
-
 Homo sapiens
-
1.2.1.5 brain
-
 Homo sapiens
-
1.2.1.5 liver
-
 Homo sapiens
-
1.2.1.18 brain
-
 Homo sapiens
-
1.2.1.18 liver
-
 Homo sapiens
-
1.2.1.24 brain
-
 Homo sapiens
-
1.2.1.24 liver
-
 Homo sapiens
-
1.2.1.31 brain
-
 Homo sapiens
-
1.2.1.31 liver
-
 Homo sapiens
-
1.2.1.36 brain
-
 Homo sapiens
-
1.2.1.36 liver
-
 Homo sapiens
-
1.2.1.41 brain
-
 Homo sapiens
-
1.2.1.41 liver
-
 Homo sapiens
-
1.2.1.47 brain
-
 Homo sapiens
-
1.2.1.47 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O
-
 Homo sapiens 3,4-dihydroxyphenylacetate + NADH + H+
-
 ?
1.2.1.3 3,4-dihydroxyphenylglycolaldehyde + NAD+ + H2O
-
 Homo sapiens 3,4-dihydroxyphenylglycolate + NADH + H+
-
 ?
1.2.1.3 acetaldehyde + NAD+ + H2O
-
 Homo sapiens acetate + NADH + H+
-
 ?
1.2.1.3 acetaldehyde + NAD+ + H2O preferred substrate of isozyme ALDH2 Homo sapiens acetate + NADH + H+
-
 ?
1.2.1.3 retinal + NAD+ + H2O
-
 Homo sapiens retinoic acid + NADH + H+
-
 ?
1.2.1.5 3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O
-
 Homo sapiens 3,4-dihydroxyphenylacetate + NADH + H+
-
 ?
1.2.1.5 3,4-dihydroxyphenylglycolaldehyde + NAD+ + H2O
-
 Homo sapiens 3,4-dihydroxyphenylglycolate + NADH + H+
-
 ?
1.2.1.5 retinal + NAD+ + H2O preferred substrate of isozyme ALDH1A3 Homo sapiens retinoic acid + NADH + H+
-
 ?
1.2.1.24 succinate semialdehyde + NAD+ + H2O
-
 Homo sapiens succinate + NADH + H+
-
 ?
1.2.1.31 alpha-aminoadipic semialdehyde + NAD+ + H2O
-
 Homo sapiens alpha-aminoadipic acid + NADH + H+
-
 ?
1.2.1.36 retinal + NAD+ + H2O
-
 Homo sapiens retinoic acid + NADH + H+
-
 ?
1.2.1.41 glutamate gamma-semialdehyde + NAD+ + H2O
-
 Homo sapiens L-glutamate + NADH + H+
-
 ?
1.2.1.47 gamma-aminobutyraldehyde + NAD+ + H2O
-
 Homo sapiens 4-aminobutanoate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.3 ALDH1A1
-
 Homo sapiens
1.2.1.3 Aldh1b1
-
 Homo sapiens
1.2.1.3 ALDH2
-
 Homo sapiens
1.2.1.3 Aldh8a1
-
 Homo sapiens
1.2.1.5 Aldh1a3
-
 Homo sapiens
1.2.1.5 ALDH3A1
-
 Homo sapiens
1.2.1.5 Aldh3b1
-
 Homo sapiens
1.2.1.18 Aldh6a1
-
 Homo sapiens
1.2.1.24 ALDH5A1
-
 Homo sapiens
1.2.1.31 Aldh7a1
-
 Homo sapiens
1.2.1.36 Aldh1a2
-
 Homo sapiens
1.2.1.41 Aldh18a1
-
 Homo sapiens
1.2.1.47 Aldh9a1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 NAD+ required Homo sapiens
1.2.1.5 NAD+ required Homo sapiens
1.2.1.18 NAD+ required Homo sapiens
1.2.1.24 NAD+ required Homo sapiens
1.2.1.31 NAD+ required Homo sapiens
1.2.1.36 NAD+ required Homo sapiens
1.2.1.41 NAD+ required Homo sapiens
1.2.1.47 NAD+ required Homo sapiens