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Literature summary extracted from

  • Mittal, A.; Phillips, A.R.; Loveday, B.; Windsor, J.A.
    The potential role for xanthine oxidase inhibition in major intra-abdominal surgery (2008), World J. Surg., 32, 288-295.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.3.2 allopurinol
-
 Felis silvestris
1.17.3.2 allopurinol
-
 Homo sapiens
1.17.3.2 allopurinol
-
 Mus musculus
1.17.3.2 allopurinol
-
 Rattus norvegicus
1.17.3.2 apigenin
-
 Homo sapiens
1.17.3.2 apigenin
-
 Rattus norvegicus
1.17.3.2 epicatechin
-
 Homo sapiens
1.17.3.2 epicatechin
-
 Rattus norvegicus
1.17.3.2 green tea extract
-
 Homo sapiens
1.17.3.2 green tea extract
-
 Rattus norvegicus
1.17.3.2 luteolin
-
 Homo sapiens
1.17.3.2 luteolin
-
 Rattus norvegicus
1.17.3.2 quercetin
-
 Homo sapiens
1.17.3.2 quercetin
-
 Rattus norvegicus
1.17.3.2 Tungsten
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.3.2 additional information Mus musculus xanthine oxidase inhibition in small intestine ischemia-reperfusion injury leads to prevention of intestine necrosis ?
-
 ?
1.17.3.2 additional information Felis silvestris xanthine oxidase inhibition in small intestine ischemia-reperfusion injury leads to reduction in neutrophil infiltration ?
-
 ?
1.17.3.2 additional information Rattus norvegicus xanthine oxidase inhibition in small intestine ischemia-reperfusion injury leads to reduction in villar necrosis, reduced intestinal MPO levels, reduced circulating neutrophil priming and reduction in pulmonary damage, prevention of permeability changes in intestinal mucosa, reduction in length of necrotic small bowel by 60%, reduction in intestinal apoptosis and tissue MDA levels; reduction in plasma MDA levels and improvement in renal function, and improved small intestine anastomotic healing and animal survival, overview ?
-
 ?
1.17.3.2 xanthine + H2O + O2 Mus musculus the enzyme plays a role in the development of distant organ dysfunction after abdominal surgery, overview urate + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 Homo sapiens the enzyme plays a role in the development of distant organ dysfunction after abdominal surgery, overview urate + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 Rattus norvegicus the enzyme plays a role in the development of distant organ dysfunction after abdominal surgery, overview urate + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 Felis silvestris the enzyme plays a role in the development of distant organ dysfunction after abdominal surgery, overview urate + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Felis silvestris
-
 f. catus
-
1.17.3.2 Homo sapiens
-
-
-
1.17.3.2 Mus musculus
-
-
-
1.17.3.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.3.2 small intestine
-
 Mus musculus
-
1.17.3.2 small intestine
-
 Homo sapiens
-
1.17.3.2 small intestine
-
 Rattus norvegicus
-
1.17.3.2 small intestine
-
 Felis silvestris
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.3.2 additional information xanthine oxidase inhibition in small intestine ischemia-reperfusion injury leads to prevention of intestine necrosis Mus musculus ?
-
 ?
1.17.3.2 additional information xanthine oxidase inhibition in small intestine ischemia-reperfusion injury leads to reduction in neutrophil infiltration Felis silvestris ?
-
 ?
1.17.3.2 additional information xanthine oxidase inhibition in small intestine ischemia-reperfusion injury leads to reduction in villar necrosis, reduced intestinal MPO levels, reduced circulating neutrophil priming and reduction in pulmonary damage, prevention of permeability changes in intestinal mucosa, reduction in length of necrotic small bowel by 60%, reduction in intestinal apoptosis and tissue MDA levels; reduction in plasma MDA levels and improvement in renal function, and improved small intestine anastomotic healing and animal survival, overview Rattus norvegicus ?
-
 ?
1.17.3.2 xanthine + H2O + O2 production of superoxide radicals Mus musculus urate + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 production of superoxide radicals Homo sapiens urate + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 production of superoxide radicals Rattus norvegicus urate + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 production of superoxide radicals Felis silvestris urate + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 the enzyme plays a role in the development of distant organ dysfunction after abdominal surgery, overview Mus musculus urate + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 the enzyme plays a role in the development of distant organ dysfunction after abdominal surgery, overview Homo sapiens urate + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 the enzyme plays a role in the development of distant organ dysfunction after abdominal surgery, overview Rattus norvegicus urate + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 the enzyme plays a role in the development of distant organ dysfunction after abdominal surgery, overview Felis silvestris urate + H2O2
-
 ?