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Literature summary extracted from

  • Kitamura, Y.; Kawase, M.; Ohmori, S.
    Formate excretion in urine of rats fed dimethylaminoazobenzene-rich diets: the possibility of formate formation from D-lactate (2008), Acta Med. Okayama, 62, 193-203.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.6 lactoylglutathione + H2O Rattus norvegicus reaction is rate-limiting, methylglyoxal bypass of glycolysis D-lactate + glutathione
-
 r
4.4.1.5 additional information Rattus norvegicus glyoxalase I catalyzes the isomerization reaction of thiohemiacetal, which is formed nonenzymatically from methylglyoxal and glutathione ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.6 Rattus norvegicus
-
 (SPF/VAF)-strain albino rats
-
4.4.1.5 Rattus norvegicus
-
 (SPF/VAF)-strain albino rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.6 liver
-
 Rattus norvegicus
-
4.4.1.5 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.2.6 additional information
-
 activity is determined spectrophotometrically at 240 nm, the hepatic glyoxalase II activity of the 3'-methyl-4-dimethylaminoazobenzene group (10 weeks fed) is almost the same as that of the control group Rattus norvegicus
3.1.2.6 additional information
-
 determined spectrophotometrically at 240 nm, glyoxalase II activities of 2-methyl-4-dimethylaminoazobenzene-fed rats (10 weeks fed) are 1.3 times higher than that of the control rats Rattus norvegicus
3.1.2.6 additional information
-
 determined spectrophotometrically at 240 nm, glyoxalase II activities of 4'-methyl-4-dimethylaminoazobenzene-fed rats (10 weeks fed) are 1.4 times higher than that of the control rats Rattus norvegicus
4.4.1.5 additional information
-
 determined spectrophotometrically at 240 nm, glyoxalase I activities for 2-methyl-4-dimethylaminoazobenzene-fed rats (10 weeks fed) are 1.7times higher than that of control animals Rattus norvegicus
4.4.1.5 additional information
-
 determined spectrophotometrically at 240 nm, glyoxalase I activities for 3'-methyl-4-dimethylaminoazobenzene-fed rats (10 weeks fed) are 1.6times higher than that of control animals Rattus norvegicus
4.4.1.5 additional information
-
 determined spectrophotometrically at 240 nm, glyoxalase I activities for 4'-methyl-4-dimethylaminoazobenzene-fed rats (10 weeks fed) are 1.5times higher than that of control animals Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.6 lactoylglutathione + H2O reaction is rate-limiting, methylglyoxal bypass of glycolysis Rattus norvegicus D-lactate + glutathione
-
 r
4.4.1.5 additional information glyoxalase I catalyzes the isomerization reaction of thiohemiacetal, which is formed nonenzymatically from methylglyoxal and glutathione Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.2.6 glyoxalase II
-
 Rattus norvegicus
3.1.2.6 hydroxyacylglutathione hydrolase
-
 Rattus norvegicus
4.4.1.5 glyoxalase I
-
 Rattus norvegicus
4.4.1.5 lactoylglutathione lyase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
4.4.1.5 glutathione
-
 Rattus norvegicus