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Literature summary extracted from

  • Kundu, T.K.; Hille, R.; Velayutham, M.; Zweier, J.L.
    Characterization of superoxide production from aldehyde oxidase: an important source of oxidants in biological tissues (2007), Arch. Biochem. Biophys., 460, 113-121.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.2.3.1 medicine aldehyde oxidase can be an important basal source of superoxide that will be enhanced in disease settings where cellular aldehyde levels are increased Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.3.1 menadione
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.3.1 cytosol
-
 Rattus norvegicus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.3.1 150000
-
 1 * 150000, SDS-PAGE Rattus norvegicus
1.2.3.1 290000
-
 gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.2.3.1 Rattus norvegicus Q9Z0U5
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.3.1 1667fold by gel filtration with a yield of 12%, to more than 98% purity Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.3.1 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.3.1 1.08
-
 liver homogenate Rattus norvegicus
1.2.3.1 1.8
-
 1667fold purified enzyme Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.3.1 p-dimethyl aminocinnamaldehyde + H2O + O2
-
 Rattus norvegicus ? + H2O2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.3.1 monomer 1 * 150000, SDS-PAGE Rattus norvegicus