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Literature summary extracted from

  • Xu, P.; Oum, L.; Geacintov, N.E.; Broyde, S.
    Nucleotide selectivity opposite a benzo[a]pyrene-derived N2-dG adduct in a Y-family DNA polymerase: a 5'-slippage mechanism (2008), Biochemistry, 47, 2701-2709.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.7 deoxynucleoside triphosphate + DNAn Saccharolobus solfataricus
-
 diphosphate + DNAn+1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.7 Saccharolobus solfataricus Q97W02
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.7.7 a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 modelling and simulation of the reaction mechanism, detailed overview Saccharolobus solfataricus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Saccharolobus solfataricus diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn nucleotide selectivity opposite a benzo[a]pyrene-derived N2-dG adduct in DNA polymerase IV, 5'-slippage mechanism: the dATP can be inserted opposite the T on the 5' side of the adduct G1*, in which the unadducted G2, rather than G1*, is skipped, to produce a -1 deletion, molecular modeling and dynamics simulations, overview Saccharolobus solfataricus diphosphate + DNAn+1
-
 ?
2.7.7.7 additional information significant preferential dATP insertion, dATP can be misincorporated opposite the benzo[a]pyrene-derived N2-dG adduct, standing-start single-nucleotide insertion assays, overview Saccharolobus solfataricus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.7 DNA polymerase IV
-
 Saccharolobus solfataricus
2.7.7.7 Dpo4
-
 Saccharolobus solfataricus
2.7.7.7 More the enzyme belongs to the Y-family polymerases Saccharolobus solfataricus