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Literature summary extracted from

  • Cooper, C.E.; Mason, M.G.; Nicholls, P.
    A dynamic model of nitric oxide inhibition of mitochondrial cytochrome c oxidase (2008), Biochim. Biophys. Acta, 1777, 867-876.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.9 NO simple dynamic steady-state non-equilibrium model. Binding to the oxidase is always proportional to the degree of inhibition of oxygen consumption. Primary effect of NO binding to the oxidised enzyme is to convert NO to nitrite, rather than to inhibit enzyme activity synthetic construct

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.9 mitochondrion
-
 synthetic construct 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.9 synthetic construct
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.9 ferrocytochrome c + O2 + H+
-
 synthetic construct ferricytochrome c + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.9 cytochrome c oxidase
-
 synthetic construct
7.1.1.9 cytochrome oxidase
-
 synthetic construct

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.9 heme a
-
 synthetic construct