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Literature summary extracted from

  • Bidmon, H.J.; Goerg, B.; Palomero-Gallagher, N.; Schleicher, A.; Haeussinger, D.; Speckmann, E.J.; Zilles, K.
    Glutamine synthetase becomes nitrated and its activity is reduced during repetitive seizure activity in the pentylentetrazole model of epilepsy (2008), Epilepsia, 49, 1733-1748.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.1.2 L-methionine-sulfoximine
-
Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.1.2 Mg2+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.1.2 ATP + L-glutamate + NH3 Rattus norvegicus the astrocyte-specific glutamine synthetase plays a key role in glutamate recycling and gamma-aminobutyric acid metabolism, it is involved in nitrosative stress response in the brain, overview ADP + phosphate + L-glutamine
-
?
6.3.1.2 additional information Rattus norvegicus rats with pentylenetetrazole-induced repetitive epileptic seizures show increased heat shock responseand reduced enzyme activity, overview ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
6.3.1.2 Rattus norvegicus
-
male Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.1.2 astrocyte astrocyte-specific glutamine synthetase Rattus norvegicus
-
6.3.1.2 cerebral cortex
-
Rattus norvegicus
-
6.3.1.2 hippocampus
-
Rattus norvegicus
-
6.3.1.2 additional information enzyme immunohistochemic analysis, overview Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.1.2 ATP + L-glutamate + NH3
-
Rattus norvegicus ADP + phosphate + L-glutamine
-
?
6.3.1.2 ATP + L-glutamate + NH3 the astrocyte-specific glutamine synthetase plays a key role in glutamate recycling and gamma-aminobutyric acid metabolism, it is involved in nitrosative stress response in the brain, overview Rattus norvegicus ADP + phosphate + L-glutamine
-
?
6.3.1.2 additional information rats with pentylenetetrazole-induced repetitive epileptic seizures show increased heat shock responseand reduced enzyme activity, overview Rattus norvegicus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
6.3.1.2 Glutamine synthetase
-
Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
6.3.1.2 37
-
assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.1.2 6.8
-
assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.1.2 ATP
-
Rattus norvegicus