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Literature summary extracted from

  • Jia, Z.; Guo, X.; Zhang, H.; Wang, M.H.; Dong, Z.; Yang, T.
    Microsomal prostaglandin synthase-1-derived prostaglandin E2 protects against angiotensin II-induced hypertension via inhibition of oxidative stress (2008), Hypertension, 52, 952-959.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.3.99.3 angiotensin II angiotension II infusion induces mRNA expression of mPGES-1, mPGES-2 and cytosolic PGE synthase Mus musculus

Application

EC Number Application Comment Organism
5.3.99.3 medicine mPGES-1 is a potential target of anti-inflammatory drugs Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.99.3 membrane
-
 Mus musculus 16020
-
5.3.99.3 microsome
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.3 (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Mus musculus
-
 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.3 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.3 vascular cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.3 (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
 Mus musculus (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.3 microsomal PG synthase-1
-
 Mus musculus
5.3.99.3 microsomal prostaglandin synthase-1
-
 Mus musculus
5.3.99.3 mPGES-1
-
 Mus musculus
5.3.99.3 prostaglandin synthase-1
-
 Mus musculus
5.3.99.3 prostaglandin-E synthase
-
 Mus musculus