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Literature summary extracted from

  • Savvi, S.; Warner, D.F.; Kana, B.D.; McKinney, J.D.; Mizrahi, V.; Dawes, S.S.
    Functional characterization of a vitamin B12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: implications for propionate metabolism during growth on fatty acids (2008), J. Bacteriol., 190, 3886-3895.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.3.1 3-nitropropionate 0.1 mM, inhibition of bacterial growth on and metabolisation of proprionate as sole carbon in absence of Vitamin B12 Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
4.1.3.1 Mycobacterium tuberculosis
-
 H37Rv, ATCC 25618, without functional ICL2 gene (aceA) because gene is split into two ORFs (aceAa and aceAb)
-
5.4.99.2 Mycobacterium tuberculosis
-
-
-
5.4.99.2 Mycobacterium tuberculosis H37Rv
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.2 (R)-2-methylmalonyl-CoA
-
 Mycobacterium tuberculosis succinyl-CoA
-
 r
5.4.99.2 (R)-2-methylmalonyl-CoA
-
 Mycobacterium tuberculosis H37Rv succinyl-CoA
-
 r

Subunits

EC Number Subunits Comment Organism
5.4.99.2 heterodimer
-
 Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
4.1.3.1 citrate lyase
-
 Mycobacterium tuberculosis
4.1.3.1 ICL ICL1 with isocitrate and 2-methylisocitrate lyase activity Mycobacterium tuberculosis
5.4.99.2 MCM
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
5.4.99.2 adenosylcobalamin dependent on Mycobacterium tuberculosis