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Literature summary extracted from

  • Fernandez-Pinar, R.; Ramos, J.L.; Rodríguez-Herva, J.J.; Espinosa-Urgel, M.
    A two-component regulatory system integrates redox state and population density sensing in Pseudomonas putida (2008), J. Bacteriol., 190, 7666-7674.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.13.3 Expression of wild-type and RoxRS mutant strain EU58 (mutant of two-component system) in Escherichia coli Pseudomonas putida

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.13.3 additional information Pseudomonas putida significant number of genes are influenced directly or indirectly by the RoxSR two-component system. 173 genes are found showing reduced expression in EU58 (RoxSR mutant strain) in comparison to the wild type, whereas 84 genes are upregulated in the mutant ?
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 ?
2.7.13.3 additional information Pseudomonas putida The two-component system is implicated in redox signaling and cytochrome oxidase activity, in expression of the cell density-dependent gene ddcA and in bacterial colonization of plant surfaces. The RoxS/RoxR regulon includes genes involved in sugar and amino acid metabolism and the sulfur starvation response and elements of the respiratory chain (a cbb3 cytochrome oxidase, Fe-S clusters, and cytochrome c-related proteins) or genes participating in the maintenance of the redox balance. The RoxS/RoxR system controls a broad set of functions that have an influence on energy metabolism, such as formaldehyde and formate dehydrogenases. ?
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 ?
2.7.13.3 additional information Pseudomonas putida KT 2240 significant number of genes are influenced directly or indirectly by the RoxSR two-component system. 173 genes are found showing reduced expression in EU58 (RoxSR mutant strain) in comparison to the wild type, whereas 84 genes are upregulated in the mutant ?
-
 ?
2.7.13.3 additional information Pseudomonas putida KT 2240 The two-component system is implicated in redox signaling and cytochrome oxidase activity, in expression of the cell density-dependent gene ddcA and in bacterial colonization of plant surfaces. The RoxS/RoxR regulon includes genes involved in sugar and amino acid metabolism and the sulfur starvation response and elements of the respiratory chain (a cbb3 cytochrome oxidase, Fe-S clusters, and cytochrome c-related proteins) or genes participating in the maintenance of the redox balance. The RoxS/RoxR system controls a broad set of functions that have an influence on energy metabolism, such as formaldehyde and formate dehydrogenases. ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.13.3 Pseudomonas putida Q88PG3 sensor protein, the two components are encoded by PP_0887 (roxS, sensor protein) and PP_0888 (roxR, response regulator) which are transcribed in a single unit.
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2.7.13.3 Pseudomonas putida KT 2240 Q88PG3 sensor protein, the two components are encoded by PP_0887 (roxS, sensor protein) and PP_0888 (roxR, response regulator) which are transcribed in a single unit.
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.13.3 additional information significant number of genes are influenced directly or indirectly by the RoxSR two-component system. 173 genes are found showing reduced expression in EU58 (RoxSR mutant strain) in comparison to the wild type, whereas 84 genes are upregulated in the mutant Pseudomonas putida ?
-
 ?
2.7.13.3 additional information The two-component system is implicated in redox signaling and cytochrome oxidase activity, in expression of the cell density-dependent gene ddcA and in bacterial colonization of plant surfaces. The RoxS/RoxR regulon includes genes involved in sugar and amino acid metabolism and the sulfur starvation response and elements of the respiratory chain (a cbb3 cytochrome oxidase, Fe-S clusters, and cytochrome c-related proteins) or genes participating in the maintenance of the redox balance. The RoxS/RoxR system controls a broad set of functions that have an influence on energy metabolism, such as formaldehyde and formate dehydrogenases. Pseudomonas putida ?
-
 ?
2.7.13.3 additional information significant number of genes are influenced directly or indirectly by the RoxSR two-component system. 173 genes are found showing reduced expression in EU58 (RoxSR mutant strain) in comparison to the wild type, whereas 84 genes are upregulated in the mutant Pseudomonas putida KT 2240 ?
-
 ?
2.7.13.3 additional information The two-component system is implicated in redox signaling and cytochrome oxidase activity, in expression of the cell density-dependent gene ddcA and in bacterial colonization of plant surfaces. The RoxS/RoxR regulon includes genes involved in sugar and amino acid metabolism and the sulfur starvation response and elements of the respiratory chain (a cbb3 cytochrome oxidase, Fe-S clusters, and cytochrome c-related proteins) or genes participating in the maintenance of the redox balance. The RoxS/RoxR system controls a broad set of functions that have an influence on energy metabolism, such as formaldehyde and formate dehydrogenases. Pseudomonas putida KT 2240 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.13.3 sensor histidine kinase two-component system formed by sensor histidine kinase and a response regulator Pseudomonas putida
2.7.13.3 sensor protein roxS
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 Pseudomonas putida