EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.26 | D-galactarate | induces KGSADH-II | Azospirillum brasilense | |
1.2.1.26 | D-glucarate | induces KGSADH-II | Azospirillum brasilense | |
1.2.1.26 | hydroxy-L-proline | induces KGSADH-III | Azospirillum brasilense | |
1.2.1.26 | L-arabinose | induces KGSADH-I | Azospirillum brasilense |
EC Number | Application | Comment | Organism |
---|---|---|---|
1.2.1.26 | additional information | the ALDH branch including ycbD protein is designated the KGSADH subclass (type III) | Bacillus subtilis |
1.2.1.26 | additional information | three different types of KGSADH appear in the bacterial evolutional stage convergently | Azospirillum brasilense |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.2.1.26 | expressed as His6-tagged ycbD protein | Bacillus subtilis |
1.2.1.26 | KGSADH-II overexpressed as His6-tagged protein in Escherichia coli DH5alpha | Azospirillum brasilense |
1.2.1.26 | KGSADH-III overexpressed as His6-tagged protein in Escherichia coli DH5alpha | Azospirillum brasilense |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.26 | 0.0065 | - |
alpha-Ketoglutaric semialdehyde | with NAD+ as cofactor | Azospirillum brasilense | |
1.2.1.26 | 0.0075 | - |
alpha-Ketoglutaric semialdehyde | with NADP+ as cofactor | Azospirillum brasilense | |
1.2.1.26 | 0.011 | - |
alpha-Ketoglutaric semialdehyde | with NADP+ as cofactor | Azospirillum brasilense | |
1.2.1.26 | 0.0149 | - |
NADP+ | - |
Azospirillum brasilense | |
1.2.1.26 | 0.0246 | - |
alpha-Ketoglutaric semialdehyde | with NAD+ as cofactor | Azospirillum brasilense | |
1.2.1.26 | 0.0352 | - |
Octylaldehyde | - |
Bacillus subtilis | |
1.2.1.26 | 0.0393 | - |
heptaldehyde | - |
Bacillus subtilis | |
1.2.1.26 | 0.0622 | - |
NADP+ | - |
Azospirillum brasilense | |
1.2.1.26 | 0.0814 | - |
hexylaldehyde | - |
Bacillus subtilis | |
1.2.1.26 | 0.094 | - |
alpha-Ketoglutaric semialdehyde | with NADP+ as cofactor | Bacillus subtilis | |
1.2.1.26 | 0.1169 | - |
NAD+ | - |
Azospirillum brasilense | |
1.2.1.26 | 0.145 | - |
Valeraldehyde | - |
Bacillus subtilis | |
1.2.1.26 | 0.17 | - |
butylaldehyde | - |
Bacillus subtilis | |
1.2.1.26 | 0.2599 | - |
NAD+ | KGSADH-I | Azospirillum brasilense | |
1.2.1.26 | 0.5569 | - |
alpha-Ketoglutaric semialdehyde | with NAD+ as cofactor | Bacillus subtilis | |
1.2.1.26 | 0.74 | - |
NAD+ | - |
Bacillus subtilis | |
1.2.1.26 | 1.08 | - |
NADP+ | - |
Bacillus subtilis | |
1.2.1.26 | 1.136 | - |
NAD+ | - |
Azospirillum brasilense | |
1.2.1.26 | 1.46 | - |
propionaldehyde | - |
Bacillus subtilis | |
1.2.1.26 | 2.427 | - |
NADP+ | KGSADH-I | Azospirillum brasilense |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.2.1.26 | 12000 | - |
gel filtration | Azospirillum brasilense |
1.2.1.26 | 54351 | - |
2 * 57000 or 2 * 54351, gel filtration | Azospirillum brasilense |
1.2.1.26 | 55185 | - |
2 * 57000 or 2 * 55185, gel filtration | Azospirillum brasilense |
1.2.1.26 | 57000 | - |
2 * 57000 or 2 * 54351, gel filtration | Azospirillum brasilense |
1.2.1.26 | 57000 | - |
2 * 57000 or 2 * 55185, gel filtration | Azospirillum brasilense |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.26 | Azospirillum brasilense | Q08IB7 | strain ATCC29145 | - |
1.2.1.26 | Azospirillum brasilense | Q08IC0 | strain ATCC29145 | - |
1.2.1.26 | Azospirillum brasilense | Q1JUP4 | strain ATCC29145 | - |
1.2.1.26 | Azospirillum brasilense ATCC 29145 | Q08IB7 | strain ATCC29145 | - |
1.2.1.26 | Azospirillum brasilense ATCC 29145 | Q08IC0 | strain ATCC29145 | - |
1.2.1.26 | Azospirillum brasilense ATCC 29145 | Q1JUP4 | strain ATCC29145 | - |
1.2.1.26 | Bacillus subtilis | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.2.1.26 | KGSADH-II purified on nickel-nitrilotriacetic acid spin column and by gel filtration | Azospirillum brasilense |
1.2.1.26 | KGSADH-III purified on nickel-nitrilotriacetic acid spin column and by gel filtration | Azospirillum brasilense |
EC Number | Storage Stability | Organism |
---|---|---|
1.2.1.26 | -35°C, buffer E, pH 8.0, 250 mM imidazole | Azospirillum brasilense |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.26 | 2,5-dioxopentanoate + NAD+ + H2O | - |
Bacillus subtilis | 2-oxoglutarate + NADH + H+ | - |
r | |
1.2.1.26 | 2,5-dioxopentanoate + NAD+ + H2O | - |
Azospirillum brasilense | 2-oxoglutarate + NADH + H+ | - |
r | |
1.2.1.26 | 2,5-dioxopentanoate + NAD+ + H2O | - |
Azospirillum brasilense ATCC 29145 | 2-oxoglutarate + NADH + H+ | - |
r | |
1.2.1.26 | alpha-ketoglutaric semialdehyde + NAD(P)+ + H2O | - |
Bacillus subtilis | alpha-ketoglutarate + NAD(P)H + H+ | - |
? | |
1.2.1.26 | alpha-ketoglutaric semialdehyde + NAD(P)+ + H2O | - |
Azospirillum brasilense | alpha-ketoglutarate + NAD(P)H + H+ | - |
? | |
1.2.1.26 | alpha-ketoglutaric semialdehyde + NAD(P)+ + H2O | - |
Azospirillum brasilense ATCC 29145 | alpha-ketoglutarate + NAD(P)H + H+ | - |
? | |
1.2.1.26 | butyraldehyde + NAD(P)+ + H2O | - |
Bacillus subtilis | n-butanoate + NAD(P)H + H+ | - |
? | |
1.2.1.26 | heptaldehyde + NAD(P)+ + H2O | - |
Bacillus subtilis | n-heptanoate + NAD(P)H + H+ | - |
? | |
1.2.1.26 | hexylaldehyde + NAD(P)+ + H2O | - |
Bacillus subtilis | n-hexanoate + NAD(P)H + H+ | - |
? | |
1.2.1.26 | octylaldehyde + NAD(P)+ + H2O | - |
Bacillus subtilis | n-octanoate + NAD(P)H + H+ | - |
? | |
1.2.1.26 | propionaldehyde + NAD(P)+ + H2O | - |
Bacillus subtilis | propionate + NAD(P)H + H+ | - |
? | |
1.2.1.26 | valeraldehyde + NAD(P)+ + H2O | - |
Bacillus subtilis | n-pentanoate + NAD(P)H + H+ | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.2.1.26 | dimer | 2 * 57000 or 2 * 54351, gel filtration | Azospirillum brasilense |
1.2.1.26 | dimer | 2 * 57000 or 2 * 55185, gel filtration | Azospirillum brasilense |
1.2.1.26 | tetramer | gel filtration | Bacillus subtilis |
1.2.1.26 | tetramer | gel filtration | Azospirillum brasilense |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.2.1.26 | alpha-ketoglutaric semialdehyde dehydrogenase | - |
Bacillus subtilis |
1.2.1.26 | alpha-ketoglutaric semialdehyde dehydrogenase | - |
Azospirillum brasilense |
1.2.1.26 | alphaKGSA dehydrogenase | - |
Bacillus subtilis |
1.2.1.26 | alphaKGSA dehydrogenase | - |
Azospirillum brasilense |
1.2.1.26 | KGSADH | - |
Bacillus subtilis |
1.2.1.26 | KGSADH-I | - |
Azospirillum brasilense |
1.2.1.26 | KGSADH-II | - |
Azospirillum brasilense |
1.2.1.26 | KGSADH-III | - |
Azospirillum brasilense |
1.2.1.26 | ycbD protein | - |
Bacillus subtilis |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.26 | 0.74 | - |
NAD+ | - |
Bacillus subtilis | |
1.2.1.26 | 0.87 | - |
heptaldehyde | - |
Bacillus subtilis | |
1.2.1.26 | 0.97 | - |
Octylaldehyde | - |
Bacillus subtilis | |
1.2.1.26 | 1.08 | - |
NADP+ | - |
Bacillus subtilis | |
1.2.1.26 | 1.12 | - |
alpha-Ketoglutaric semialdehyde | with NAD+ as cofactor | Bacillus subtilis | |
1.2.1.26 | 1.29 | - |
propionaldehyde | - |
Bacillus subtilis | |
1.2.1.26 | 1.35 | - |
butylaldehyde | - |
Bacillus subtilis | |
1.2.1.26 | 1.47 | - |
hexylaldehyde | - |
Bacillus subtilis | |
1.2.1.26 | 2.1 | - |
Valeraldehyde | - |
Bacillus subtilis | |
1.2.1.26 | 2.75 | - |
alpha-Ketoglutaric semialdehyde | with NADP+ as cofactor | Bacillus subtilis | |
1.2.1.26 | 9.86 | - |
NADP+ | KGSADH-I | Azospirillum brasilense | |
1.2.1.26 | 10.2 | - |
NADP+ | - |
Azospirillum brasilense | |
1.2.1.26 | 15.3 | - |
NADP+ | - |
Azospirillum brasilense | |
1.2.1.26 | 15.4 | - |
alpha-Ketoglutaric semialdehyde | with NADP+ as cofactor | Azospirillum brasilense | |
1.2.1.26 | 16.7 | - |
NAD+ | KGSADH-I | Azospirillum brasilense | |
1.2.1.26 | 21.3 | - |
alpha-Ketoglutaric semialdehyde | with NAD+ as cofactor | Azospirillum brasilense | |
1.2.1.26 | 23 | - |
alpha-Ketoglutaric semialdehyde | with NADP+ as cofactor | Azospirillum brasilense | |
1.2.1.26 | 35.5 | - |
NAD+ | - |
Azospirillum brasilense | |
1.2.1.26 | 52.3 | - |
NAD+ | - |
Azospirillum brasilense | |
1.2.1.26 | 53.9 | - |
alpha-Ketoglutaric semialdehyde | with NAD+ as cofactor | Azospirillum brasilense |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.26 | NAD+ | - |
Bacillus subtilis | |
1.2.1.26 | NAD+ | - |
Azospirillum brasilense | |
1.2.1.26 | NAD+ | no significant preference between NAD+ and NADP+ in activity | Azospirillum brasilense | |
1.2.1.26 | NAD+ | prefered cofactor of KGSADH-II | Azospirillum brasilense | |
1.2.1.26 | NADP+ | - |
Bacillus subtilis | |
1.2.1.26 | NADP+ | - |
Azospirillum brasilense | |
1.2.1.26 | NADP+ | prefered cofactor of KGSADH-III | Azospirillum brasilense |