EC Number | Application | Comment | Organism |
---|---|---|---|
1.2.1.48 | medicine | direct link between FALDH inactivation and disease pathology of Sjögren-Larsson syndrome caused by accumulation of alcohols | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.2.1.48 | recombinant His6-FADH expressed in Escherichia coli BL21(DE3) | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.2.1.48 | D245N | NAD+ cosubstrate binding is occuring but catalytic reduction is diminished | Homo sapiens |
1.2.1.48 | G185A | disruption of NAD+ binding/utilisation | Homo sapiens |
1.2.1.48 | G412R | disruption of interaction of side-chains with substrate | Homo sapiens |
1.2.1.48 | H411Y | disruption of the key abstraction of the hydroxyl hydrogen | Homo sapiens |
1.2.1.48 | Q445R | substitution in the recombinant protein | Homo sapiens |
1.2.1.48 | T184M | disruption of NAD+ binding/utilisation | Homo sapiens |
1.2.1.48 | T184R | disruption of NAD+ binding/utilisation | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.48 | 0.0038 | - |
decanal | - |
Homo sapiens | |
1.2.1.48 | 0.0083 | - |
hexadecanal | - |
Homo sapiens | |
1.2.1.48 | 0.0103 | - |
Tetradecanal | - |
Homo sapiens | |
1.2.1.48 | 0.0136 | - |
dodecanal | - |
Homo sapiens | |
1.2.1.48 | 0.02 | - |
octadecanal | - |
Homo sapiens | |
1.2.1.48 | 0.023 | - |
farnesal | - |
Homo sapiens | |
1.2.1.48 | 0.0343 | - |
(11Z)-hexadec-11-enal | - |
Homo sapiens | |
1.2.1.48 | 0.18 | - |
NAD+ | - |
Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.2.1.48 | microsome | - |
Homo sapiens | - |
- |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.2.1.48 | 57000 | - |
x * 57000, SDS-PAGE | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.48 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.2.1.48 | recombinant His6-FADH purified by anion exchange and metal-chelate chromatography, to 90-95% purity | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.48 | cis-11-hexadecenal + NAD+ + H2O | - |
Homo sapiens | cis-11-hexadecenoic acid + NADH + H+ | - |
? | |
1.2.1.48 | decanal + NAD+ + H2O | - |
Homo sapiens | decanoic acid + NADH + H+ | - |
? | |
1.2.1.48 | dodecanal + NAD+ + H2O | - |
Homo sapiens | dodecanoic acid + NADH + H+ | - |
? | |
1.2.1.48 | farnesal + NAD+ + H2O | - |
Homo sapiens | farnesoic acid + NADH + H+ | - |
? | |
1.2.1.48 | heptanal + NAD+ + H2O | - |
Homo sapiens | heptanoic acid + NADH + H+ | - |
? | |
1.2.1.48 | hexadecanal + NAD+ + H2O | - |
Homo sapiens | hexadecanoic acid + NADH + H+ | - |
? | |
1.2.1.48 | additional information | catalytically important residues to be involved in alcohol and aldehyde oxidation are Gln-120, Glu-207, Cys-241, Phe-333, Tyr-410 and His-411 | Homo sapiens | ? | - |
? | |
1.2.1.48 | octadecanal + NAD+ + H2O | - |
Homo sapiens | octadecanoic acid + NADH + H+ | - |
? | |
1.2.1.48 | octanal + NAD+ + H2O | - |
Homo sapiens | octanoic acid + NADH + H+ | - |
? | |
1.2.1.48 | tetradecanal + NAD+ + H2O | - |
Homo sapiens | tetradecanoic acid + NADH + H+ | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.2.1.48 | ? | x * 57000, SDS-PAGE | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.2.1.48 | FALDH | - |
Homo sapiens |
1.2.1.48 | fatty aldehyde dehydrogenase | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.2.1.48 | 35 | - |
- |
Homo sapiens |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.48 | 0.86 | - |
Tetradecanal | - |
Homo sapiens | |
1.2.1.48 | 0.93 | - |
farnesal | - |
Homo sapiens | |
1.2.1.48 | 0.95 | - |
hexadecanal | - |
Homo sapiens | |
1.2.1.48 | 1.28 | - |
NAD+ | - |
Homo sapiens | |
1.2.1.48 | 1.4 | - |
(11Z)-hexadec-11-enal | - |
Homo sapiens | |
1.2.1.48 | 1.52 | - |
octadecanal | - |
Homo sapiens | |
1.2.1.48 | 2.18 | - |
decanal | - |
Homo sapiens | |
1.2.1.48 | 2.23 | - |
dodecanal | - |
Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.2.1.48 | 9.5 | - |
- |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.48 | NAD+ | - |
Homo sapiens |