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Literature summary extracted from

  • De Backer, O.; Elinck, E.; Sips, P.; Buys, E.; Brouckaert, P.; Lefebvre, R.A.
    Role of the soluble guanylyl cyclase alpha1/alpha2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus (2008), Naunyn Schmiedebergs Arch. Pharmacol., 378, 493-502.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.2 CO
-
 Mus musculus
4.6.1.2 CORM-2 i.e. CO-releasing molecule-2, a tricarbonyldichlororuthenium(II) dimer Mus musculus
4.6.1.2 YC-1 i.e. 1-benzyl-3-(5'-hydroxymethyl-2'-furyl-)-indazol, a sGC sensitizer, able to potentiate CO- and CORM-2-induced relaxations in wild-type mice Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
4.6.1.2 additional information construction and phenotype of sGCalpha1 KO mice, expression levels of sGC subunits are altered in the mutant compared to the wild-type mice, the KO mice show reduced enzyme activation and induced muscle relaxation by CO, overview Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.2 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one i.e. ODQ, a sGC inhibitor Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.2 soluble
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.2 GTP Mus musculus
-
 3',5'-cyclic GMP + diphosphate
-
 ?
4.6.1.2 additional information Mus musculus soluble guanylyl cyclase alpha1/alpha2 subunits are involved in the relaxant effect of CO and CORM-2, i.e. CO-releasing molecule-2, on enteric smooth muscle, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.2 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.2 intestine
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.2 GTP
-
 Mus musculus 3',5'-cyclic GMP + diphosphate
-
 ?
4.6.1.2 additional information soluble guanylyl cyclase alpha1/alpha2 subunits are involved in the relaxant effect of CO and CORM-2, i.e. CO-releasing molecule-2, on enteric smooth muscle, overview Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.2 sGC
-
 Mus musculus
4.6.1.2 soluble guanylyl cyclase
-
 Mus musculus