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Literature summary extracted from

  • Sauer, S.W.; Koelker, S.; Hoffmann, G.F.; Ten Brink, H.J.; Jakobs, C.; Gibson, K.M.; Okun, J.G.
    Enzymatic and metabolic evidence for a region specific mitochondrial dysfunction in brains of murine succinic semialdehyde dehydrogenase deficiency (Aldh5a1-/- mice) (2007), Neurochem. Int., 50, 653-659.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.2.1.24 medicine SSADH (Aldh5a1) deficiency is a rare autosomal recessive disease. Hippocampal and cortical dysfunction in Aldh5a1-/- brain, but no evidence that accumulating key metabolites of SSADH deficiency directly induce impairment of energy metabolism Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
1.2.1.24 additional information Aldh5a1-/- mice show abnormalities of respiratory chain function. Hippocampus and cortex are primary targets for neurodegeneration Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.24 mitochondrion
-
 Mus musculus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.24 Mus musculus Q8BWF0
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.24 brain cortex
-
 Mus musculus
-
1.2.1.24 hippocampus
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.24 succinate semialdehyde + NAD+ + H2O
-
 Mus musculus succinate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.24 ALDH5A1
-
 Mus musculus
1.2.1.24 SSADH
-
 Mus musculus
1.2.1.24 succinic semialdehyde dehydrogenase
-
 Mus musculus