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Literature summary extracted from

  • Attallah, C.V.; Welchen, E.; Pujol, C.; Bonnard, G.; Gonzalez, D.H.
    Characterization of Arabidopsis thaliana genes encoding functional homologues of the yeast metal chaperone Cox19p, involved in cytochrome c oxidase biogenesis (2007), Plant Mol. Biol., 65, 343-355.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.1.1.9 3-Amino-1,2,4-triazole
-
 Arabidopsis thaliana
7.1.1.9 salicylic acid produces a slight and transient increase in transcript levels of COX19 Arabidopsis thaliana
7.1.1.9 sodium nitroprusside produces a several fold increase in COX19 expression after 4 h of treatment, but transcript levels return to normal values after higher incubation times Arabidopsis thaliana

Application

EC Number Application Comment Organism
7.1.1.9 additional information Arabidopsis thaliana COX19 genes encode functional homologues of the yeast metal chaperone. Smaller COX19-1 isoform, but not the larger one, is able to restore growth on non-fermentable carbon sources when expressed in a yeast cox19 null mutant. Induction by biotic and abiotic stress factors may indicate a relevant role of this protein in the biogenesis of cytochrome c oxidase to replace damaged forms of the enzyme. COX19 has additional functions besides its participation in COX assembly as, for example, metal transport, detoxification, or general protection against oxidative stress Arabidopsis thaliana

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.1.1.9 cDNAs from both COX19-1 splice variants cloned in the sense and antisense orientations in plasmid pYPGE15, containing a constitutive phosphoglycerate kinase gene promoter and a CYC1 terminator. Expressed in a yeast cox19 null mutant Arabidopsis thaliana

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.9 additional information import of COX19 is not inhibited by the ionophore valinomycin indicating that an electrical membrane potential is not required Arabidopsis thaliana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.9 inner membrane AtCOX19 isoforms are imported into mitochondria in vitro and are attached to the inner membrane facing the intermembrane space Arabidopsis thaliana
-
-
7.1.1.9 mitochondrion
-
 Arabidopsis thaliana 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.1.1.9 Cu2+ increases COX19 transcript levels Arabidopsis thaliana
7.1.1.9 Fe2+
-
 Arabidopsis thaliana
7.1.1.9 Zn2+
-
 Arabidopsis thaliana

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.9 Arabidopsis thaliana
-
 ecotype Columbia
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.9 anther highly stained in AtCOX19-1::GUS plants Arabidopsis thaliana
-
7.1.1.9 leaf expression in leaves is only observed when cuts are produced, suggesting an induction by wounding Arabidopsis thaliana
-
7.1.1.9 additional information infection of plants with the pathogenic bacterium Pseudomonas syringae pv. tomato induces COX19 gene expression Arabidopsis thaliana
-
7.1.1.9 root highly stained in AtCOX19-1::GUS plants. Activity in roots is already evident at very early stages of development (1-2 days after imbibition), but not in embryos at late stages of embryogenesis and is higher in the root meristem, the vascular cylinder and nascent secondary roots Arabidopsis thaliana
-

Synonyms

EC Number Synonyms Comment Organism
7.1.1.9 COX19
-
 Arabidopsis thaliana
7.1.1.9 cytochrome c oxidase
-
 Arabidopsis thaliana