Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Jung, H.A.; Yoon, N.Y.; Bae, H.J.; Min, B.S.; Choi, J.S.
    Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase (2008), Arch. Pharm. Res., 31, 1405-1412.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.21
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 coptisine 53.85-61.54% inhibition at 0.075 mg/ml Homo sapiens
1.1.1.21 coptisine 85.86-86.87% inhibition at 0.05 mg/ml Rattus norvegicus
1.1.1.21 epiberberine 69.23-76.92% inhibition at 0.075 mg/ml Homo sapiens
1.1.1.21 epiberberine complete inhibition at 0.05 mg/ml Rattus norvegicus
1.1.1.21 groenlandicine 69.23-76.92% inhibition at 0.075 mg/ml Homo sapiens
1.1.1.21 groenlandicine 52.38-60.32% inhibition at 0.05 mg/ml Rattus norvegicus
1.1.1.21 jateorrhizine 12.68-14.08% inhibition at 0.05 mg/ml Rattus norvegicus
1.1.1.21 magnoflorine 18.33-29.85% inhibition at 0.05 mg/ml Rattus norvegicus
1.1.1.21 additional information berberine and palmatine exhibit no RLAR inhibitory activities within the test concentration of 0.012.5-0.05 mg/ml; extract and fractions of the rhizome of Coptis chinensis exhibit broad and moderate RLAR inhibitory activities of approximately 0.038.9-0.067.5 mg/ml Rattus norvegicus
1.1.1.21 quercetin
-
 Homo sapiens
1.1.1.21 quercetin 76.47-77.94% inhibition at 0.005 mg/ml Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Homo sapiens
-
-
-
1.1.1.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 lens
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.21 DL-glyceraldehyde + NADPH + H+
-
 Homo sapiens glycerol + NADP+
-
 ?
1.1.1.21 DL-glyceraldehyde + NADPH + H+
-
 Rattus norvegicus glycerol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.21 aldose reductase
-
 Homo sapiens
1.1.1.21 aldose reductase
-
 Rattus norvegicus
1.1.1.21 HRAR
-
 Homo sapiens
1.1.1.21 RLAR
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.21 NADPH
-
 Homo sapiens
1.1.1.21 NADPH
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.21 0.0188
-
 in 100 mM sodium phosphate buffer (pH 6.2) Rattus norvegicus quercetin
1.1.1.21 0.1
-
 in 100 mM sodium phosphate buffer (pH 6.2) Rattus norvegicus epiberberine
1.1.1.21 0.1184
-
 in 100 mM sodium phosphate buffer (pH 6.2) Rattus norvegicus coptisine
1.1.1.21 0.1401
-
 in 100 mM sodium phosphate buffer (pH 6.2) Rattus norvegicus groenlandicine
1.1.1.21 0.1542
-
 in 100 mM sodium phosphate buffer (pH 6.2) Homo sapiens groenlandicine
1.1.1.21 0.1681
-
 in 100 mM sodium phosphate buffer (pH 6.2) Homo sapiens epiberberine
1.1.1.21 0.1873
-
 in 100 mM sodium phosphate buffer (pH 6.2) Homo sapiens coptisine