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Literature summary extracted from

  • Chethan, S.; Dharmesh, S.M.; Malleshi, N.G.
    Inhibition of aldose reductase from cataracted eye lenses by finger millet (Eleusine coracana) polyphenols (2008), Bioorg. Med. Chem., 16, 10085-10090.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 4-hydroxybenzoic acid
-
 Homo sapiens
1.1.1.21 ferulic acid
-
 Homo sapiens
1.1.1.21 gallic acid
-
 Homo sapiens
1.1.1.21 p-catechuic acid
-
 Homo sapiens
1.1.1.21 p-coumaric acid
-
 Homo sapiens
1.1.1.21 quercetin
-
 Homo sapiens
1.1.1.21 syringic acid
-
 Homo sapiens
1.1.1.21 trans-cinnamic acid
-
 Homo sapiens
1.1.1.21 vanillic acid
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 lens
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.21 D-glucose + NADPH + H+
-
 Homo sapiens sorbitol + NADP+
-
 ?
1.1.1.21 DL-glyceraldehyde + NADPH + H+
-
 Homo sapiens glycerol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.21 alditol: NADP+ 1-oxidoreductase
-
 Homo sapiens
1.1.1.21 aldose reductase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.21 NADPH
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.21 additional information
-
 gallic acid IC50: 0.0973 mg/ml, p-coumaric acid IC50: 0.1623 mg/ml, syringic acid IC50: 0.1721 mg/ml, trans-cinnamic acid IC50: 0.0681 mg/ml, p-catechuic acid IC50: 0.0427 mg/ml, quercetin IC50: 0.02523 mg/ml (in 50 mM sodium potassium phosphate buffer (pH 6.0) containing 5 mM beta-mercaptoethanol, 0.7 M NADPH, 0.4 M Li2SO4, and 2.5 mM of DL-glyceraldehyde) Homo sapiens additional information