Literature summary extracted from

Sooksa-nguan, T.; Yakubov, B.; Kozlovskyy, V.I.; Barkume, C.M.; Howe, K.J.; Thannhauser, T.W.; Rutzke, M.A.; Hart, J.J.; Kochian, L.V.; Rea, P.A.; Vatamaniuk, O.K.
Drosophila ABC transporter, DmHMT-1, confers tolerance to cadmium. DmHMT-1 and its yeast homolog, SpHMT-1, are not essential for vacuolar phytochelatin sequestration (2009), J. Biol. Chem., 284, 354-362.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
7.2.2.2	expression in Schizosaccharomyces pombe	Drosophila melanogaster
7.2.2.2	phylogenetic analysis	Schizosaccharomyces pombe

Protein Variants

EC Number	Protein Variants	Comment	Organism
7.2.2.2	additional information	heterologously expressed DmHMT-1 suppresses the Cd2+ hypersensitivity of Schizosaccharomyces pombe hmt-1 mutants and localizes to the vacuolar membrane but does not transport Cd-PCc, phenotype, overview	Drosophila melanogaster
7.2.2.2	additional information	SpHMT-1-deficient cells are hypersensitive to Cd2+, but not to Hg2+ or As3+, heterologously expressed Drosophila melanogaster HMT-1 suppresses the Cd2+ hypersensitivity of Schizosaccharomyces pombe hmt-1 mutants and localizes to the vacuolar membrane but does not transport Cd-PCc, overview	Schizosaccharomyces pombe

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
7.2.2.2	vacuolar membrane	-	Schizosaccharomyces pombe	5774	-
7.2.2.2	vacuolar membrane	-	Drosophila melanogaster	5774	-

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
7.2.2.2	97900	-	x * 97900	Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
7.2.2.2	ATP + H2O + Cd2+/in	Drosophila melanogaster	ABC transporter, DmHMT-1, confers tolerance to cadmium. DmHMT-1 and its yeast homolog, SpHMT-1, are not essential for vacuolar phytochelatin sequestration	ADP + phosphate + Cd2+/out	-	?
7.2.2.2	ATP + H2O + Cd2+/in	Schizosaccharomyces pombe	ABC transporter, HMT-1, confers tolerance to cadmium. HMT-1 is not essential for vacuolar phytochelatin sequestration. HMT-1 either does not transport Cd-PC complexes or is not the principal Cd-PC/apoPC transporter	ADP + phosphate + Cd2+/in	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
7.2.2.2	Drosophila melanogaster	Q9VF20	-	-
7.2.2.2	Schizosaccharomyces pombe	-	wild-type strain YF01	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
7.2.2.2	ATP + H2O + Cd2+/in	-	Schizosaccharomyces pombe	ADP + phosphate + Cd2+/out	-	?
7.2.2.2	ATP + H2O + Cd2+/in	-	Drosophila melanogaster	ADP + phosphate + Cd2+/out	-	?
7.2.2.2	ATP + H2O + Cd2+/in	ABC transporter, DmHMT-1, confers tolerance to cadmium. DmHMT-1 and its yeast homolog, SpHMT-1, are not essential for vacuolar phytochelatin sequestration	Drosophila melanogaster	ADP + phosphate + Cd2+/out	-	?
7.2.2.2	ATP + H2O + Cd2+/in	ABC transporter, HMT-1, confers tolerance to cadmium. HMT-1 is not essential for vacuolar phytochelatin sequestration. HMT-1 either does not transport Cd-PC complexes or is not the principal Cd-PC/apoPC transporter	Schizosaccharomyces pombe	ADP + phosphate + Cd2+/in	-	?

Subunits

EC Number	Subunits	Comment	Organism
7.2.2.2	?	x * 97900	Drosophila melanogaster

Synonyms

EC Number	Synonyms	Comment	Organism
7.2.2.2	heavy metal tolerance factor 1	-	Schizosaccharomyces pombe
7.2.2.2	heavy metal tolerance factor 1	-	Drosophila melanogaster
7.2.2.2	HMT-1	-	Schizosaccharomyces pombe
7.2.2.2	HMT-1	-	Drosophila melanogaster

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
7.2.2.2	ATP	-	Schizosaccharomyces pombe
7.2.2.2	ATP	-	Drosophila melanogaster

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Release 2023.1 (January 2023)