EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.B40 | 18beta-glycyrrhetinic acid | inhibits both 11beta-HSD1 and 11beta-HSD2, but preferentially inhibits 11beta-HSD2 | Homo sapiens | |
1.1.1.B40 | additional information | 18alpha-glycyrrhetinic acid, selective inhibition of 11beta-HSD1, does not inhibit 11beta-HSD2 at concentrations up to 0.02 mM | Homo sapiens | |
1.1.1.146 | 18alpha-glycyrrhetinic acid | selective inhibition of 11beta-HSD1, does not inhibit 11beta-HSD2 at concentrations up to 0.02 mM | Homo sapiens | |
1.1.1.146 | 18beta-glycyrrhetinic acid | inhibits both 11beta-HSD1 and 11beta-HSD2, but preferentially inhibits 11beta-HSD2 | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.B40 | cortisol + NAD+ | Homo sapiens | - |
cortisone + NADH | - |
ir | |
1.1.1.146 | cortisol + NADP+ | Homo sapiens | - |
cortisone + NADPH | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.B40 | Homo sapiens | - |
- |
- |
1.1.1.146 | Homo sapiens | P28845 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.B40 | cortisol + NAD+ | - |
Homo sapiens | cortisone + NADH | - |
ir | |
1.1.1.146 | cortisol + NADP+ | - |
Homo sapiens | cortisone + NADPH | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.B40 | 11beta-HSD2 | - |
Homo sapiens |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase 2 | - |
Homo sapiens |
1.1.1.146 | 11beta-HSD1 | - |
Homo sapiens |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase 1 | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.1.1.B40 | 37 | - |
assay at | Homo sapiens |
1.1.1.146 | 37 | - |
assay at | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.B40 | NAD+ | - |
Homo sapiens | |
1.1.1.146 | NADP+ | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.1.1.B40 | 0.000257 | - |
37°C, pH not specified in the publication | Homo sapiens | 18beta-glycyrrhetinic acid | |
1.1.1.146 | 0.000779 | - |
37°C, pH not specified in the publication | Homo sapiens | 18beta-glycyrrhetinic acid | |
1.1.1.146 | 0.002214 | - |
37°C, pH not specified in the publication | Homo sapiens | 18alpha-glycyrrhetinic acid |