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Literature summary extracted from

  • Wang, D.Y.; Lu, Q.; Walsh, S.L.; Payne, L.; Modha, S.S.; Scott, M.J.; Sweitzer, T.D.; Ames, R.S.; Krosky, D.J.; Li, H.
    Development of a high-throughput cell-based assay for 11beta-hydroxysteroid dehydrogenase type 1 using BacMam technology (2008), Mol. Biotechnol., 39, 127-134.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.146 expressed in HEK-293 cells, co-expression of hexose-6-phosphate dehydrogenase is not required for the enzyme to function effectively as an oxo-reductase Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.146 18beta-glycyrrhetinic acid 11beta-HSD1 inhibitor with submicromolar potency Homo sapiens
1.1.1.146 18beta-glycyrrhetinic acid 11beta-HSD1 inhibitor with submicromolar potency Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.146 33500
-
 calculated from amino acid sequence Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Homo sapiens
-
-
-
1.1.1.146 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.146 3T3-L1 cell
-
 Mus musculus
-
1.1.1.146 adipocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 cortisol + NADP+
-
 Mus musculus cortisone + NADPH
-
 r
1.1.1.146 cortisol + NADP+
-
 Homo sapiens cortisone + NADPH
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.146 11beta-HSD1
-
 Mus musculus
1.1.1.146 11beta-HSD1
-
 Homo sapiens
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
 Mus musculus
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.146 NADP+
-
 Mus musculus
1.1.1.146 NADP+
-
 Homo sapiens