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Literature summary extracted from

  • de Souza, A.M.; Lara, L.d.a..S.; Previato, J.O.; Lopes, A.G.; Caruso-Neves, C.; da Silva, B.P.; Parente, J.P.
    Modulation of sodium pumps by steroidal saponins (2008), Z. Naturforsch. C, 59, 432-436.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.3 (3beta,22alpha,25R)-26-(beta-D-glucopyranosyloxy)-2-methoxyfurost-5-en-3-yl O-D-apio-beta-D-furanosyl-(1-2)-O-[6-deoxy-alpha-L-mannopyranosyl-(1-4)]-beta-D-glucopyranoside
-
 Sus scrofa
7.2.2.3 (3beta,22alpha,25R)-spirostan-3-yl O-D-apio-beta-D-furanosyl-(1-2)-O-[6-deoxy-alpha-L-mannopyranosyl-(1-4)]-beta-D-glucopyranoside
-
 Sus scrofa
7.2.2.3 Furosemide
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.2.2.3 3 3.2 Na+ in the presence of 0.00001 mM (3beta,22alpha,25R)-spirostan-3-yl O-D-apio-beta-D-furanosyl-(1-2)-O-[6-deoxy-alpha-L-mannopyranosyl-(1-4)]-beta-D-glucopyranoside Sus scrofa
7.2.2.3 5.8
-
 Na+
-
 Sus scrofa
7.2.2.3 56.7
-
 Na+ in the presence of 0.00001 mM (3beta,22alpha,25R)-26-(beta-D-glucopyranosyloxy)-2-methoxyfurost-5-en-3-yl O-D-apio-beta-D-furanosyl-(1-2)-O-[6-deoxy-alpha-L-mannopyranosyl-(1-4)]-beta-D-glucopyranoside Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.3 basolateral plasma membrane
-
 Sus scrofa 16323
-

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.3 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.3 kidney
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.3 ATP + H2O + Na+/in
-
 Sus scrofa ADP + phosphate + Na+/out
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.3 Na+-ATPase
-
 Sus scrofa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
7.2.2.3 0.000001
-
 obtained by extrapolation of half maximal inhibition Sus scrofa (3beta,22alpha,25R)-spirostan-3-yl O-D-apio-beta-D-furanosyl-(1-2)-O-[6-deoxy-alpha-L-mannopyranosyl-(1-4)]-beta-D-glucopyranoside
7.2.2.3 0.00001
-
 obtained by extrapolation of half maximal inhibition Sus scrofa (3beta,22alpha,25R)-26-(beta-D-glucopyranosyloxy)-2-methoxyfurost-5-en-3-yl O-D-apio-beta-D-furanosyl-(1-2)-O-[6-deoxy-alpha-L-mannopyranosyl-(1-4)]-beta-D-glucopyranoside