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Literature summary extracted from

  • Nunes, S.F.; Figueiredo, I.V.; Soares, P.J.; Costa, N.E.; Lopes, M.C.; Caramona, M.M.
    Semicarbazide-sensitive amine oxidase activity and total nitrite and nitrate concentrations in serum: novel biochemical markers for type 2 diabetes? (2009), Acta Diabetol., 46, 135-140.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.4.3.21 copper dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.21 aminoacetone + H2O + O2 Homo sapiens
-
methylglyoxal + NH3 + H2O2
-
?
1.4.3.21 methylamine + H2O + O2 Homo sapiens
-
formaldehyde + NH3 + H2O2
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.21 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.21 adipocyte
-
Homo sapiens
-
1.4.3.21 eye
-
Homo sapiens
-
1.4.3.21 heart
-
Homo sapiens
-
1.4.3.21 kidney
-
Homo sapiens
-
1.4.3.21 liver
-
Homo sapiens
-
1.4.3.21 lung
-
Homo sapiens
-
1.4.3.21 pancreas
-
Homo sapiens
-
1.4.3.21 placenta
-
Homo sapiens
-
1.4.3.21 serum significantly elevated serum SSAO activity in diabetic patients, overview Homo sapiens
-
1.4.3.21 vascular smooth muscle cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.21 aminoacetone + H2O + O2
-
Homo sapiens methylglyoxal + NH3 + H2O2
-
?
1.4.3.21 benzylamine + H2O + O2
-
Homo sapiens benzaldehyde + NH3 + H2O2
-
?
1.4.3.21 methylamine + H2O + O2
-
Homo sapiens formaldehyde + NH3 + H2O2
-
?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.21 semicarbazide-sensitive amine oxidase
-
Homo sapiens
1.4.3.21 SSAO
-
Homo sapiens
1.4.3.21 VAP-1
-
Homo sapiens
1.4.3.21 vascular adhesion protein-1
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.4.3.21 37
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.3.21 7.4
-
assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.21 2,4,5-trihydroxyphenylalaninequinone i.e. TPQ cofactor Homo sapiens

General Information

EC Number General Information Comment Organism
1.4.3.21 physiological function SSAO is also known as vascular adhesion protein-1 and acts as one of the adhesion molecules involved in lymphocytes trafficking. Increased serum SSAO/VAP-1 mediates tissue-selective lymphocyte adhesion and thus it may be involved in inflammatory liver cirrhosis and congestive heart failure Homo sapiens