EC Number | Application | Comment | Organism |
---|---|---|---|
1.14.14.154 | drug development | the humanized yeast strain provides a useful tool for initial specificity testing for new drugs targeting CYP51 and clearly differentiates azole antifungals in a side-by-side comparison | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.14.14.154 | expressed in Saccharomyces cerevisiae BY4741 under the control of the yeast CYP51 promoter | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.154 | clotrimazole | - |
Homo sapiens | |
1.14.14.154 | clotrimazole | - |
Saccharomyces cerevisiae | |
1.14.14.154 | econazole | - |
Homo sapiens | |
1.14.14.154 | econazole | - |
Saccharomyces cerevisiae | |
1.14.14.154 | fluconazole | - |
Homo sapiens | |
1.14.14.154 | fluconazole | - |
Saccharomyces cerevisiae | |
1.14.14.154 | itraconazole | - |
Homo sapiens | |
1.14.14.154 | itraconazole | - |
Saccharomyces cerevisiae | |
1.14.14.154 | ketoconazole | - |
Homo sapiens | |
1.14.14.154 | ketoconazole | - |
Saccharomyces cerevisiae | |
1.14.14.154 | miconazole | - |
Homo sapiens | |
1.14.14.154 | miconazole | - |
Saccharomyces cerevisiae | |
1.14.14.154 | additional information | humanized yeast strain as compared to the parental yeast strain shows up to 1000fold reduced susceptibility to the orally active azole drugs and reduced effectiveness for the topical drugs | Homo sapiens | |
1.14.14.154 | additional information | the parental yeast strain as compared to humanized yeast strain shows up to 1000fold higher susceptibility to the orally active azole drugs | Saccharomyces cerevisiae | |
1.14.14.154 | voriconazole | displays the greatest specificity | Homo sapiens | |
1.14.14.154 | voriconazole | displays the greatest specificity | Saccharomyces cerevisiae |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.14.154 | membrane | - |
Homo sapiens | 16020 | - |
1.14.14.154 | microsome | - |
Homo sapiens | - |
- |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.154 | Homo sapiens | Q16850 | - |
- |
1.14.14.154 | Saccharomyces cerevisiae | - |
- |
- |
1.14.14.154 | Saccharomyces cerevisiae BY4741 | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.154 | lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Saccharomyces cerevisiae | ? + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.154 | lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.154 | lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Saccharomyces cerevisiae BY4741 | ? + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.14.154 | CYP51 | - |
Saccharomyces cerevisiae |
1.14.14.154 | CYP51 | - |
Homo sapiens |
1.14.14.154 | Erg11p | - |
Saccharomyces cerevisiae |
1.14.14.154 | Erg11p | - |
Homo sapiens |