Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Sova, M.; Cadez, G.; Turk, S.; Majce, V.; Polanc, S.; Batson, S.; Lloyd, A.J.; Roper, D.I.; Fishwick, C.W.; Gobec, S.
    Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB) (2009), Bioorg. Med. Chem. Lett., 19, 1376-1379.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.2.1 1-[[(4-fluorophenyl)sulfonyl]amino]-3-(morpholin-4-yl)propan-2-yl dihydrogen phosphate 75% inhibition at 0.5 mM Enterococcus faecium
6.1.2.1 1-[[(4-fluorophenyl)sulfonyl]amino]-3-(morpholin-4-yl)propan-2-yl phenyl hydrogen phosphate 65% inhibition at 0.5 mM Enterococcus faecium
6.1.2.1 1-[[(4-methoxyphenyl)sulfonyl]amino]-3-(morpholin-4-yl)propan-2-yl dihydrogen phosphate 83% inhibition at 0.5 mM Enterococcus faecium
6.3.2.4 1-[[(4-fluorophenyl)sulfonyl]amino]-3-(morpholin-4-yl)propan-2-yl dihydrogen phosphate 0.5 mM, 75% inhibition Enterococcus faecium
6.3.2.4 1-[[(4-fluorophenyl)sulfonyl]amino]-3-(morpholin-4-yl)propan-2-yl dihydrogen phosphate 0.5 mM, 77% inhibition Escherichia coli
6.3.2.4 1-[[(4-fluorophenyl)sulfonyl]amino]-3-(morpholin-4-yl)propan-2-yl phenyl hydrogen phosphate 0.5 mM, 65% inhibition Enterococcus faecium
6.3.2.4 1-[[(4-methoxyphenyl)sulfonyl]amino]-3-(morpholin-4-yl)propan-2-yl dihydrogen phosphate 0.5 mM, 83% inhibition Enterococcus faecium
6.3.2.4 1-[[(4-methoxyphenyl)sulfonyl]amino]-3-(morpholin-4-yl)propan-2-yl dihydrogen phosphate 0.5 mM, 83% inhibition Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
6.1.2.1 Enterococcus faecium
-
 isoform VanA
-
6.3.2.4 Enterococcus faecium
-
 isoform VanA
-
6.3.2.4 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.4 ATP + 2 D-Ala
-
 Escherichia coli ADP + phosphate + D-Ala-D-Ala
-
 ?
6.3.2.4 ATP + 2 D-Ala
-
 Enterococcus faecium ADP + phosphate + D-Ala-D-Ala
-
 ?
6.3.2.4 ATP + D-Ala + D-lactate enzyme uses both D-Ala and D-lactate as a substrate Enterococcus faecium ADP + phosphate + D-Ala-D-lactate
-
 ?