EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.17.1.4 | sodium nitroprusside | i.e. SNP, a NO donor, activates at concentrations of up to 3 mM, preventable by hemoglobin, overview | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.17.1.4 | ammonium acetate | inhibits the enzyme in vivo after injection into the brain, blocked by MK-801, which alone does not affect the enzyme activity itself | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.17.1.4 | cytosol | - |
Rattus norvegicus | 5829 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.1.4 | xanthine + NAD+ + H2O | Rattus norvegicus | - |
urate + NADH + H+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.17.1.4 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.17.1.4 | brain | - |
Rattus norvegicus | - |
1.17.1.4 | forebrain | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.1.4 | xanthine + NAD+ + H2O | - |
Rattus norvegicus | urate + NADH + H+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.17.1.4 | xanthine:NAD+ oxidoreductase | - |
Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.17.1.4 | NAD+ | - |
Rattus norvegicus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.17.1.4 | metabolism | xanthine dehydrogenase is an enzyme form of the xanthine dehydrogenase/oxidase enzyme, XDH, complex, that catalyzes the end step in the purine catabolic pathway and is directly involved in depletion of the adenylate pool in the cell | Rattus norvegicus |