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Literature summary extracted from

  • Moriguchi, T.; Ebizuka, Y.; Fujii, I.
    Domain-domain interactions in the iterative type I polyketide synthase ATX from Aspergillus terreus (2008), ChemBioChem, 9, 1207-1212.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.165 expressed in Saccharomyces cerevisiae Aspergillus terreus

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.165 C216A mutant without catalytic activity Aspergillus terreus
2.3.1.165 H939A mutant with catalytic activity Aspergillus terreus
2.3.1.165 additional information deletion of one of the 6-methylsalicylic acid synthase domains ketosynthase, acyltransferase, dehydratase, ketoreductase, or acyl carrier protein results in a lost of catalytic activity Aspergillus terreus
2.3.1.165 S1761A mutant without catalytic activity Aspergillus terreus
2.3.1.165 S667A mutant without catalytic activity Aspergillus terreus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.165 190000
-
-
 Penicillium griseofulvum

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.165 Aspergillus terreus
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-
-
2.3.1.165 Penicillium griseofulvum
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-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.165 acetyl-CoA + malonyl-CoA + NADPH
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 Aspergillus terreus 6-methylsalicylate + CoA + CO2 + NADP+
-
 ?
2.3.1.165 acetyl-CoA + malonyl-CoA + NADPH
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 Penicillium griseofulvum 6-methylsalicylate + CoA + CO2 + NADP+
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.165 homotetramer every subunit of 6-methylsalicylic acid synthase from Aspergillus terreus consist of ketosynthase (KS), acyltransferase (AT), dehydratase (DH), ketoreductase (KR), and acyl carrier protein (ACP) domain, proposed from deletion mutant analyses Aspergillus terreus
2.3.1.165 More 6-methylsalicylic acid synthase from Penicillium patulum consist of ketosynthase (KS), acyltransferase (AT), dehydratase (DH), ketoreductase (KR), and acyl carrier protein (ACP) domains Penicillium griseofulvum

Synonyms

EC Number Synonyms Comment Organism
2.3.1.165 6-methylsalicylic acid synthase
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 Aspergillus terreus
2.3.1.165 6-methylsalicylic acid synthase
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 Penicillium griseofulvum
2.3.1.165 6-MSA
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 Penicillium griseofulvum
2.3.1.165 ATX 6-methylsalicylic acid synthase from Aspergillus terreus Aspergillus terreus
2.3.1.165 iPKS 6-methylsalicylic acid synthase belongs to the iterative type I polyketide synthases (iPKSs), which consist of ketosynthase (KS), acyltransferase (AT), and acyl carrier protein (ACP) domains as a minimum, with additional domains such as ketoreductase (KR), methyltransferase (MeT), and Claisen cyclase (CYC), all on single polypeptides. Aspergillus terreus
2.3.1.165 iPKS 6-methylsalicylic acid synthase belongs to the iterative type I polyketide synthases (iPKSs), which consist of ketosynthase (KS), acyltransferase (AT), and acyl carrier protein (ACP) domains as a minimum, with additional domains such as ketoreductase (KR), methyltransferase (MeT), and Claisen cyclase (CYC), all on single polypeptides. Penicillium griseofulvum
2.3.1.165 iterative type I polyketide synthase 6-methylsalicylic acid synthase belongs to the iterative type I polyketide synthases (iPKSs), which consist of ketosynthase (KS), acyltransferase (AT), and acyl carrier protein (ACP) domains as a minimum, with additional domains such as ketoreductase (KR), methyltransferase (MeT), and Claisen cyclase (CYC), all on single polypeptides. Aspergillus terreus
2.3.1.165 iterative type I polyketide synthase 6-methylsalicylic acid synthase belongs to the iterative type I polyketide synthases (iPKSs), which consist of ketosynthase (KS), acyltransferase (AT), and acyl carrier protein (ACP) domains as a minimum, with additional domains such as ketoreductase (KR), methyltransferase (MeT), and Claisen cyclase (CYC), all on single polypeptides. Penicillium griseofulvum