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Literature summary extracted from

  • Fujisawa, K.; Murakami, R.; Horiguchi, T.; Noma, T.
    Adenylate kinase isozyme 2 is essential for growth and development of Drosophila melanogaster (2009), Comp. Biochem. Physiol. B, 153, 29-38.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.4.3 expressed in Escherichia coli Drosophila melanogaster

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.4.3 additional information not inhibited by N-ethylmaleimide Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.4.3 mitochondrion localized in the mitochondrial intermembrane space Drosophila melanogaster 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.4.3 27000
-
 SDS-PAGE Drosophila melanogaster

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.3 Drosophila melanogaster Q9U915
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.4.3 egg
-
 Drosophila melanogaster
-
2.7.4.3 embryo
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.3 ATP + AMP
-
 Drosophila melanogaster ADP + ADP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.4.3 adenylate kinase isozyme 2
-
 Drosophila melanogaster
2.7.4.3 AK2 isozyme Drosophila melanogaster
2.7.4.3 ATP:AMP phosphotransferase
-
 Drosophila melanogaster
2.7.4.3 DAK2
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.7.4.3 malfunction although homozygous adenylate kinsase 2 mutated embryos develop without any visible defects, their growth ceases and they die before reaching the third instar larval stage Drosophila melanogaster
2.7.4.3 physiological function maternally provided adenylate kianse 2 is sufficient for embryonic development, adenylate kinase 2 plays a critical role in adenine nucleotide metabolism in the mitochondrial intermembrane space and is essential for growth in Drosophila melanogaster Drosophila melanogaster