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Literature summary extracted from

  • Zhou, C.H.; Wu, X.H.; Wu, Y.Q.
    Nobiletin, a dietary phytochemical, inhibits vascular smooth muscle cells proliferation via calcium-mediated c-Jun N-terminal kinases pathway (2009), Eur. J. Pharmacol., 615, 55-60.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.24 angiotensin II
-
 Bos taurus

Application

EC Number Application Comment Organism
2.7.11.24 medicine inhibition of JNK by nobiletin may imply its usefulness for the treatment of cardiovascular diseases relevant to vascular smooth muscle cells growth Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.24 anthra[1-9-cd]pyrazol-6(2H)-one SP600125 Bos taurus
2.7.11.24 nobiletin inhibits angiotensin II-induced activation of JNK Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.24 Ca2+ Ca2+ dependent activation of JNK in vascular smooth muscle cells Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.24 ATP + a protein Bos taurus
-
 ADP + a phosphoprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.24 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.24 vascular smooth muscle cell obtained from thoracic aorta Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.24 ATP + a protein
-
 Bos taurus ADP + a phosphoprotein
-
 ?
2.7.11.24 ATP + c-Jun activity assay Bos taurus ADP + phosphorylated c-Jun
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.24 c-Jun N-terminal kinase
-
 Bos taurus
2.7.11.24 JNK
-
 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.24 ATP
-
 Bos taurus