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Literature summary extracted from

  • Brower-Toland, B.; Riddle, N.C.; Jiang, H.; Huisinga, K.L.; Elgin, S.C.
    Multiple SET methyltransferases are required to maintain normal heterochromatin domains in the genome of Drosophila melanogaster (2009), Genetics, 181, 1303-1319.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.355 nucleus
-
Drosophila melanogaster 5634
-

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.355 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.355 adult
-
Drosophila melanogaster
-
2.1.1.355 head
-
Drosophila melanogaster
-
2.1.1.355 larva
-
Drosophila melanogaster
-
2.1.1.355 pupa
-
Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.355 S-adenosyl-L-methionine + histone H3(K9)
-
Drosophila melanogaster ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.355 G9a
-
Drosophila melanogaster
2.1.1.355 H3K9 methyltransferase
-
Drosophila melanogaster
2.1.1.355 H3K9-specific SET domain methyltransferase
-
Drosophila melanogaster
2.1.1.355 SETDB1
-
Drosophila melanogaster
2.1.1.355 SU(VAR)3-9
-
Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.1.1.355 malfunction knockdown of G9a or SETDB1 throughout development with an ACT5C-GAL4 driver produces organism- level defects only in the case of dSETDB1 Drosophila melanogaster
2.1.1.355 physiological function SETDB1 acts to maintain heterochromatin during metamorphosis, at a later stage in development than the reported action of SU(VAR)3-9, depletion of both of these enzymes has less deleterious effect than depletion of one, SETDB1 acts as a heterochromatin maintenance factor that may be required for the persistence of earlier developmental events normally governed by SU(VAR)3-9 Drosophila melanogaster