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Literature summary extracted from

  • Tye, J.W.; Darensbourg, M.Y.; Hall, M.B.
    Refining the active site structure of iron-iron hydrogenase using computational infrared spectroscopy (2008), Inorg. Chem., 47, 2380-2388.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.12.99.6 CO binds terminally to the distal iron center Desulfovibrio vulgaris
1.12.99.6 CO binds terminally to the distal iron center Desulfovibrio vulgaris str. Hildenborough

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.12.99.6 Fe the Hred form is assigned as a mixture of an Fe(I)Fe(I) form with an open site on the distal iron center and either a Fe(I)Fe(I) form in which the distal cyanide is protonated or a Fe(II)Fe(II) form with a bridging hydride ligand. The Hox form is assigned as a valence-localized Fe(I)Fe(II) redox level with an open site at the distal iron. The Hox air form is assigned as an Fe(II)Fe(II) redox level with OH- or OOH- bound to the distal iron center that may or may not have an oxygen atom bound to one of the sulfur atoms of the dithiolate linker Desulfovibrio vulgaris
1.12.99.6 Fe the Hred form is assigned as a mixture of an Fe(I)Fe(I) form with an open site on the distal iron center and either a Fe(I)Fe(I) form in which the distal cyanide is protonated or a Fe(II)Fe(II) form with a bridging hydride ligand. The Hox form is assigned as a valence-localized Fe(I)Fe(II) redox level with an open site at the distal iron. The Hox air form is assigned as an Fe(II)Fe(II) redox level with OH- or OOH- bound to the distal iron center that may or may not have an oxygen atom bound to one of the sulfur atoms of the dithiolate linker Desulfovibrio vulgaris str. Hildenborough

Organism

EC Number Organism UniProt Comment Textmining
1.12.99.6 Desulfovibrio vulgaris
-
-
-
1.12.99.6 Desulfovibrio vulgaris str. Hildenborough
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.12.99.6 H2 + oxidized electron acceptor
-
 Desulfovibrio vulgaris H+ + reduced electron acceptor
-
 ?
1.12.99.6 H2 + oxidized electron acceptor
-
 Desulfovibrio vulgaris str. Hildenborough H+ + reduced electron acceptor
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.12.99.6 [FeFe]H2ase
-
 Desulfovibrio vulgaris
1.12.99.6 [FeFe]H2ase
-
 Desulfovibrio vulgaris str. Hildenborough