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Literature summary extracted from

  • Fox, J.T.; Stover, P.J.
    Mechanism of the internal ribosome entry site-mediated translation of serine hydroxymethyltransferase 1 (2009), J. Biol. Chem., 284, 31085-31096.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.1 L-serine + tetrahydrofolate Homo sapiens
-
 glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.2.1 MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.1 L-serine + tetrahydrofolate
-
 Homo sapiens glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.2.1 serine hydroxymethyltransferase 1
-
 Homo sapiens
2.1.2.1 SHMT1
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.1.2.1 Homo sapiens heterogeneous nuclear ribonucleoprotein H2 stimulates SHMT1 internal ribosome entry site activity by binding to the 5‘-untranslated region of the transcript and interacting with CUG-binding protein 1, CUG-binding protein 1 stimulates the internal ribosome entry site-mediated translation of SHMT1 up

General Information

EC Number General Information Comment Organism
2.1.2.1 metabolism SHMT1 is a rate-limiting enzyme in de novo thymidylate biosynthesis Homo sapiens